PARK7

Parkinsonism associated deglycase

2 disorders 2 causative 1p36.23 gene with protein product

HGNC:16369 Monarch NCBI Gene 11315 ENSG00000116288 UniProt Q99497 OMIM 602533

Aliases: DJ-1, DJ1, GATD2.

Normal function · from ai-gene-review (Q99497, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status DRAFT; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
PARK7-Related Early-Onset Parkinson Disease	causative germline	mechanism: Biallelic PARK7 Loss of Function
Parkinson's Disease	causative

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
Parkinson disease MONDO:0005180	AR	Definitive 2022-06-27	Parkinson's Disease causative

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.