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CASP1

caspase 1
4 disorders 4 no genetic record 11q22.3 gene with protein product
HGNC:1499MonarchNCBI Gene 834ENSG00000137752UniProt P29466OMIM 147678

Previous symbols: IL1BC. Aliases: ICE.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Bacterial meningitis no genetic record
mechanism: Inflammasome Activation and Pyroptosis
Leptospirosis no genetic record
mechanism: NLRP3 inflammasome complex assembly
Major Depressive Disorder no genetic record
animal model: Gsdmd, Casp1 and astrocytic Nlrp3 knockout mice under chronic mild stress
Multiple Sclerosis no genetic record
mechanism: Microglial NLRP3 Inflammasome Activation
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.