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IL22

interleukin 22
2 disorders 2 no genetic record 12q15 gene with protein product
HGNC:14900MonarchNCBI Gene 50616ENSG00000127318UniProt Q9GZX6OMIM 605330

Aliases: ILTIF, IL-21, zcyto18, IL-TIF, IL-D110, TIFa, TIFIL-23, IL-22, MGC79382, MGC79384.

Normal function · from ai-gene-review (Q9GZX6, commit 79fe13b38970) · AI-generated, not KB evidence

Interleukin-22 (IL-22) is a secreted cytokine of the IL-10 family that plays critical roles in innate immunity, tissue repair, and inflammation at barrier surfaces. Unlike most cytokines, IL-22 acts primarily on non-immune cells (epithelial cells, hepatocytes) through the IL-22R1/IL-10RB receptor complex, activating JAK-STAT signaling to promote antimicrobial defense, epithelial proliferation, and tissue regeneration. IL-22 is produced mainly by activated T cells (Th17/Th22) and innate lymphoid cells (ILC3) in response to infection and inflammation. Its activity is tightly regulated by the soluble antagonist IL-22BP (IL-22RA2), creating a balanced system essential for maintaining barrier integrity while preventing excessive tissue responses.

Interleukin-22 receptor binding activates JAK-STAT signaling in epithelial cells to induce antimicrobial peptide production
molecular function: interleukin-22 receptor binding · directly involved in: positive regulation of antimicrobial peptide production; defense response to bacterium; cell surface receptor signaling pathway via JAK-STAT · locations: extracellular region
Cytokine activity stimulates hepatocyte acute phase protein synthesis through STAT3 activation
molecular function: cytokine activity · directly involved in: acute-phase response; inflammatory response · locations: extracellular region
Interleukin-22 receptor binding promotes epithelial cell proliferation and tissue repair at barrier surfaces
molecular function: interleukin-22 receptor binding · directly involved in: epithelial cell proliferation; wound healing; innate immune response · locations: extracellular region
In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Bacterial meningitis no genetic record
mechanism: Blood-Brain Barrier Disruption
Chronic Mucocutaneous Candidiasis no genetic record
mechanism: Deficient IL-17A, IL-17F and IL-22 Production

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.