Aliases: VBCH, DAND6.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Osteoporosis | susceptibility | |
| Sclerosteosis | causative germline loss of function |
mechanism: Loss of Sclerostin (SOST Loss-of-Function); Unopposed Wnt/Beta-Catenin Osteoblast Activation
subtype: SOST-related Sclerosteosis; Van Buchem Disease
scoped to subtype: SOST-related Sclerosteosis
|
| Craniodiaphyseal Dysplasia |
untyped
Causative
germline
dominant negative
|
mechanism: Loss of Sclerostin Restraint on Osteoblastic Wnt Signaling; SOST Signal Peptide Variant with Impaired Sclerostin Secretion
|
| Van Buchem Disease |
untyped
Causative
|
|
| Autosomal Dominant Osteosclerosis Worth Type | no genetic record |
mechanism: Variant-Dependent LRP5 Antagonist Resistance
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.