WRN

WRN RecQ like helicase

2 disorders 1 causative 1 untyped 8p12 gene with protein product

HGNC:12791 Monarch NCBI Gene 7486 ENSG00000165392 UniProt Q14191 OMIM 604611

Aliases: RECQL2, RECQ3.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Familial Nonmedullary Thyroid Carcinoma	causative germline
Werner Syndrome	untyped Causative	mechanism: Restored Partial WRN Expression and Nuclear Localization; WRN Helicase-Exonuclease Loss of Function; WRN-108-Directed Exon 27 Skipping; c.3139-1G>C-Dependent WRN Pre-mRNA Missplicing treatment: WRN-108 Genotype-Restricted Exon-Skipping ASO

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
Werner syndrome MONDO:0010196	AR	Definitive 2018-10-09	Werner Syndrome untyped

Mechanism modules · computed from kb/

antisense_oligonucleotide_therapy via Werner Syndrome

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.