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TYMS

thymidylate synthetase
4 disorders 1 modifier 1 untyped 1 causative 1 no genetic record 18p11.32 gene with protein product
HGNC:12441MonarchNCBI Gene 7298ENSG00000176890UniProt P04818OMIM 188350

Previous symbols: TS. Aliases: Tsase, TMS, HsT422.

Normal function · from ai-gene-review (P04818, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
5-Fluorouracil Poisoning modifier
Dyskeratosis Congenita Digenic causative
Dyskeratosis Congenita untyped
Loss of function
mechanism: Thymidylate Synthase Deficiency
subtype: DKCD
scoped to subtype: DKCD
Methotrexate Toxicity no genetic record
mechanism: Thymidylate Synthesis Blockade

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.