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TYK2

tyrosine kinase 2
5 disorders 4 untyped 1 susceptibility 19p13.2 gene with protein product
HGNC:12440MonarchNCBI Gene 7297ENSG00000105397UniProt P29597OMIM 176941

Aliases: JTK1.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Type I Diabetes susceptibility germline
Immunodeficiency 35 untyped
Causal biallelic variant
mechanism: Biallelic TYK2 Loss-of-Function Variants
Multiple Sclerosis untyped
Risk Factor
mechanism: Th1/Th17-Mediated Neuroinflammation
Psoriasis untyped
GWAS
mechanism: IL-23/IL-17 Axis
Rheumatoid Arthritis untyped
Associated with increased risk
mechanism: JAK/STAT Signaling
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.