Aliases: TR-AP, PAF400, Tra1.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| developmental delay with or without dysmorphic facies and autism | causative de novo |
mechanism: TRRAP missense variant disrupting HAT-complex scaffold function
animal model: trrap-knockout zebrafish
|
| Hearing Loss Autosomal Dominant 75 | causative |
mechanism: Heterozygous TRRAP Missense Variants in the Tra1 HEAT Repeat Domains
animal model: trrap-depleted zebrafish (morpholino knockdown and CRISPR/Cas9 knockout)
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| complex neurodevelopmental disorder with or without congenital anomalies MONDO:0100465 | AD | Definitive 2022-07-19 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.