TNNT2

troponin T2, cardiac type

5 disorders 3 causative 2 untyped 1q32.1 gene with protein product

HGNC:11949 Monarch NCBI Gene 7139 ENSG00000118194 UniProt P45379 OMIM 191045

Previous symbols: CMH2, CMD1D. Aliases: CMPD2.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Dilated Cardiomyopathy 1D	causative	mechanism: TNNT2 Variant in Cardiac Troponin T
Hypertrophic Cardiomyopathy 2	causative	mechanism: Cardiac Troponin T Thin Filament Regulatory Defect
Restrictive Cardiomyopathy	causative	mechanism: Sarcomeric or Cytoskeletal Variant with Increased Myofilament Tension subtype: RCM3
Dilated Cardiomyopathy	untyped Pathogenic Variants	mechanism: Sarcomeric and Cytoskeletal Dysfunction
Hypertrophic Cardiomyopathy	untyped Pathogenic Variants	mechanism: Sarcomere Protein Mutations

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
dilated cardiomyopathy 1D MONDO:0011095	AD	Definitive 2026-03-04	Dilated Cardiomyopathy 1D causative
arrhythmogenic right ventricular cardiomyopathy MONDO:0016587	AD	No Known Disease Relationship 2019-07-16	arrhythmogenic right ventricular cardiomyopathy not named

Mechanism modules · computed from kb/

cardiomyopathy_maladaptive_remodeling via Dilated Cardiomyopathy 1D, Hypertrophic Cardiomyopathy 2, Restrictive Cardiomyopathy

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.