TNNC1

troponin C1, slow skeletal and cardiac type

5 disorders 2 untyped 2 causative 1 unknown 3p21.1 gene with protein product

HGNC:11943 Monarch NCBI Gene 7134 ENSG00000114854 UniProt P63316 OMIM 191040

Previous symbols: TNNC.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Dilated Cardiomyopathy 1Z	causative	mechanism: Cardiac Troponin C Variant and Thin-Filament Regulatory Defect
Hypertrophic Cardiomyopathy 13	causative	mechanism: TNNC1 Missense Variant in Cardiac Troponin C
Left ventricular noncompaction	unknown
Dilated Cardiomyopathy	untyped Pathogenic Variants	mechanism: Sarcomeric and Cytoskeletal Dysfunction
Hypertrophic Cardiomyopathy	untyped Pathogenic Variants	mechanism: Altered Calcium Handling

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
hypertrophic cardiomyopathy MONDO:0005045	AD	Definitive 2023-09-13	Hypertrophic Cardiomyopathy untyped
dilated cardiomyopathy 1Z MONDO:0012745	AD	Definitive 2026-03-04	Dilated Cardiomyopathy 1Z causative
arrhythmogenic right ventricular cardiomyopathy MONDO:0016587	AD	No Known Disease Relationship 2019-09-13	arrhythmogenic right ventricular cardiomyopathy not named

Mechanism modules · computed from kb/

cardiomyopathy_maladaptive_remodeling via Dilated Cardiomyopathy 1Z, Hypertrophic Cardiomyopathy 13

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.