TNFSF11

TNF superfamily member 11

3 disorders 1 no genetic record 1 biomarker 1 causative 13q14.11 gene with protein product

HGNC:11926 Monarch NCBI Gene 8600 ENSG00000120659 UniProt O14788 OMIM 602642

Aliases: TRANCE, RANKL, OPGL, ODF, CD254.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Bone Giant Cell Tumor	biomarker
Osteopetrosis	causative	mechanism: Defective osteoclast differentiation (osteoclast-poor forms) subtype: ARO; ARO2 scoped to subtype: ARO2
Aneurysmal Bone Cyst	no genetic record	mechanism: RANKL-Driven Osteoclast Recruitment

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
autosomal recessive osteopetrosis 2 MONDO:0009816	AR	Definitive 2024-12-02	Osteopetrosis causative

Mechanism modules · computed from kb/

osteoporosis_bone_resorption via Aneurysmal Bone Cyst

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.