TNFRSF1A

TNF receptor superfamily member 1A

3 disorders 2 untyped 1 susceptibility 12p13.31 gene with protein product

HGNC:11916 Monarch NCBI Gene 7132 ENSG00000067182 UniProt P19438 OMIM 191190

Previous symbols: TNFR1. Aliases: TNF-R, TNFAR, TNFR60, TNF-R-I, CD120a, TNF-R55.

Normal function · from ai-gene-review (P19438, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status DRAFT; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Pericarditis	susceptibility germline
Multiple Sclerosis	untyped Risk Factor	mechanism: Inflammatory Lesions
TNF Receptor-Associated Periodic Syndrome	untyped Primary causal gene

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
TNF receptor 1-associated periodic fever syndrome MONDO:0007727	AD	Definitive 2025-04-21	TNF Receptor-Associated Periodic Syndrome untyped

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.