Previous symbols: TNFA. Aliases: TNFSF2, DIF, TNF-alpha.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Brucella Melitensis Brucellosis | modifier germline | |
| Byssinosis | modifier germline | |
| Coal Workers Pneumoconiosis | susceptibility germline | |
| Immunodeficiency 127 | causative germline | |
| Silicosis | susceptibility germline | |
| Chronic_Obstructive_Pulmonary_Disease |
untyped
Tumor necrosis factor mediates systemic and airway inflammation.
|
|
| Kawasaki Disease |
untyped
Induces endothelial cell expression of ICAM-1/VCAM-1, iNOS and proinflammatory cascade
|
mechanism: Immune Response Dysregulation
|
| Multisystem Inflammatory Syndrome in Children (MIS-C) |
untyped
Implicated in cytokine storm pathophysiology
|
mechanism: Cytokine Storm
|
| Rheumatoid Arthritis |
untyped
Central proinflammatory cytokine
|
mechanism: Inflammatory Cytokine Production
|
| Amatoxin Poisoning | no genetic record |
mechanism: TNF-Mediated Amplification of Hepatocyte Injury
|
| Stevens-Johnson Syndrome | no genetic record |
mechanism: Macrophage CXCL10-CXCR3 / TNF Amplification
|
| Type 2 Diabetes Mellitus | no genetic record |
mechanism: White Adipose Tissue Inflammation
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.