Previous symbols: TGFB, DPD1. Aliases: CED, TGFbeta.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Brucella Melitensis Brucellosis | protective germline | |
| Coal Workers Pneumoconiosis | susceptibility germline | |
| Otosclerosis | susceptibility germline |
mechanism: Dysregulated TGF-beta Signaling in the Otic Capsule
|
| Androgenetic Alopecia | no genetic record |
mechanism: Increased TGF-Beta1 Secretion
|
| Asthma | no genetic record |
mechanism: SIRT1-Mediated NAD+ Signaling and Protective Deacetylation
|
| Chronic_Obstructive_Pulmonary_Disease | no genetic record |
mechanism: SIRT1-Mediated NAD+ Signaling and Protective Deacetylation
|
| Fabry disease | no genetic record |
mechanism: Fibrosis and extracellular matrix remodeling
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| inflammatory bowel disease, immunodeficiency, and encephalopathy MONDO:0032601 | AR | Limited 2024-11-19 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.