Previous symbols: VMCM. Aliases: TIE2, TIE-2, VMCM1, CD202b.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Blue Rubber Bleb Nevus Syndrome | causative somatic |
mechanism: Somatic Activating TEK Variants
animal model: HUVEC-TIE2-L914F xenograft
|
| Congenital Glaucoma | causative germline loss of function |
mechanism: Angiopoietin-TEK Signaling Insufficiency and Schlemm Canal Hypoplasia
subtype: GLC3E
scoped to subtype: GLC3E
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| TEK-related primary glaucoma MONDO:0800182 | AD | Definitive 2022-08-18 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.