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STAT4

signal transducer and activator of transcription 4
8 disorders 6 untyped 1 causative 1 susceptibility 2q32.2-q32.3 gene with protein product
HGNC:11365MonarchNCBI Gene 6775ENSG00000138378UniProt Q14765OMIM 600558
Normal function · from ai-gene-review (Q14765, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status DRAFT; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Disabling Pansclerotic Morphea of Childhood causative germline gain of function
mechanism: STAT4 SH2-Domain Gain-of-Function Signaling
Invasive Non-Typhoidal Salmonellosis susceptibility
Addison's Disease untyped
Transcription factor promoting Th1 differentiation
mechanism: Polygenic Susceptibility
Coccidioidomycosis untyped
Transcription factor for IL-12 signaling; E626G mutation increases susceptibility
mechanism: Th1/Th17 cell-mediated adaptive immunity
Rheumatoid Arthritis untyped
Associated with increased risk
mechanism: JAK/STAT Signaling
Sjogren's Syndrome untyped
Risk Factor
Systemic Lupus Erythematosus untyped
Associated
Systemic Sclerosis untyped
Risk Factor
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.