SDCCAG8

SHH signaling and ciliogenesis regulator SDCCAG8

2 disorders 1 untyped 1 causative 1q43-q44 gene with protein product

HGNC:10671 Monarch NCBI Gene 10806 ENSG00000054282 UniProt Q86SQ7 OMIM 613524

Aliases: NY-CO-8, CCCAP, SLSN7, NPHP10, BBS16.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Senior-Loken Syndrome	causative	mechanism: Ciliary Transition Zone Dysfunction subtype: SLSN7 scoped to subtype: SLSN7
Bardet-Biedl syndrome	untyped Pathogenic biallelic variants	mechanism: Ciliary transition zone and basal body dysfunction

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
Bardet-Biedl syndrome 16 MONDO:0014444	AR	Definitive 2024-08-01	no dismech entry

Mechanism modules · computed from kb/

ciliopathy_dysfunction via Bardet-Biedl syndrome, Senior-Loken Syndrome

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.