Influenza <-> Myocardial Infarction

graph LR
    Respiratory_Epithelial_Infection_and_Cytopathic_Effect["Respiratory Epithelial Infection and Cytopathic Effect"]
    Endothelial_Dysfunction_and_Thromboinflammation["Endothelial Dysfunction and Thromboinflammation"]
    Immune_competent_microvascularized_lung_on_a_chip_IC_LOC_severe_H1N1_model["Immune-competent microvascularized lung-on-a-chip (IC-LOC) severe H1N1 model"]
    Triggering_of_Acute_Myocardial_Infarction["Triggering of Acute Myocardial Infarction"]
    Inflammasome_Activation_and_Cytokine_Storm["Inflammasome Activation and Cytokine Storm"]

    Endothelial_Dysfunction_and_Thromboinflammation --> Triggering_of_Acute_Myocardial_Infarction
    Immune_competent_microvascularized_lung_on_a_chip_IC_LOC_severe_H1N1_model --> Inflammasome_Activation_and_Cytokine_Storm
    Immune_competent_microvascularized_lung_on_a_chip_IC_LOC_severe_H1N1_model --> Respiratory_Epithelial_Infection_and_Cytopathic_Effect
    Immune_competent_microvascularized_lung_on_a_chip_IC_LOC_severe_H1N1_model --> Endothelial_Dysfunction_and_Thromboinflammation

    style Respiratory_Epithelial_Infection_and_Cytopathic_Effect fill:#dbeafe
    style Endothelial_Dysfunction_and_Thromboinflammation fill:#dbeafe
    style Immune_competent_microvascularized_lung_on_a_chip_IC_LOC_severe_H1N1_model fill:#ccfbf1
    style Triggering_of_Acute_Myocardial_Infarction fill:#dbeafe
    style Inflammasome_Activation_and_Cytokine_Storm fill:#dbeafe

graph LR
    Coronary_Atherothrombosis["Coronary Atherothrombosis"]
    Arrhythmia["Arrhythmia"]
    Chest_pain["Chest pain"]
    Anti_Inflammatory___Immunomodulatory_Therapy["Anti-Inflammatory / Immunomodulatory Therapy"]
    Myocardial_Ischemia_and_Cardiomyocyte_Death["Myocardial Ischemia and Cardiomyocyte Death"]
    Human_heart_on_a_chip_ischemia_reperfusion_assay_with_endothelial_extracellular_vesicle_rescue["Human heart-on-a-chip ischemia-reperfusion assay with endothelial extracellular vesicle rescue"]
    Epicardial_myocardial_heart_on_a_chip_model_of_ischemia_reperfusion_injury["Epicardial-myocardial heart-on-a-chip model of ischemia-reperfusion injury"]
    Cardiac_Fibrosis_and_Ventricular_Remodeling["Cardiac Fibrosis and Ventricular Remodeling"]
    Elevated_cardiac_troponin["Elevated cardiac troponin"]
    Post_Infarction_Inflammation_and_Cardiac_Repair["Post-Infarction Inflammation and Cardiac Repair"]
    Congestive_heart_failure["Congestive heart failure"]
    Syncope["Syncope"]
    Reduced_left_ventricular_ejection_fraction["Reduced left ventricular ejection fraction"]
    Dyspnea["Dyspnea"]
    Bioelectronically_instrumented_heart_on_a_chip_under_acute_hypoxia["Bioelectronically instrumented heart-on-a-chip under acute hypoxia"]
    Total_lipids_in_very_small_VLDL_XS_VLDL_L["Total lipids in very small VLDL (XS-VLDL-L)"]
    Coronary_Reperfusion_PCI_or_Fibrinolysis["Coronary Reperfusion (PCI or Fibrinolysis)"]
    Elevated_CK_MB["Elevated CK-MB"]
    Myocardial_infarct_border_zone_on_a_chip["Myocardial infarct border-zone-on-a-chip"]
    Myocardial_infarction["Myocardial infarction"]
    Angina_pectoris["Angina pectoris"]
    Human_cardiac_infarct_organoid_with_an_internal_oxygen_diffusion_gradient["Human cardiac infarct organoid with an internal oxygen-diffusion gradient"]
    Ventricular_fibrillation["Ventricular fibrillation"]
    Antiplatelet_and_Antithrombotic_Therapy["Antiplatelet and Antithrombotic Therapy"]
    Phospholipids_to_total_lipids_in_small_HDL_percent_S_HDL_PL%["Phospholipids to total lipids in small HDL, percent (S-HDL-PL%)"]
    Ischemia_Reperfusion_Injury["Ischemia-Reperfusion Injury"]

    Coronary_Atherothrombosis --> Myocardial_Ischemia_and_Cardiomyocyte_Death
    Myocardial_Ischemia_and_Cardiomyocyte_Death --> Ischemia_Reperfusion_Injury
    Myocardial_Ischemia_and_Cardiomyocyte_Death --> Post_Infarction_Inflammation_and_Cardiac_Repair
    Myocardial_Ischemia_and_Cardiomyocyte_Death --> Myocardial_infarction
    Myocardial_Ischemia_and_Cardiomyocyte_Death --> Angina_pectoris
    Myocardial_Ischemia_and_Cardiomyocyte_Death --> Chest_pain
    Myocardial_Ischemia_and_Cardiomyocyte_Death --> Arrhythmia
    Myocardial_Ischemia_and_Cardiomyocyte_Death --> Reduced_left_ventricular_ejection_fraction
    Ischemia_Reperfusion_Injury --> Ventricular_fibrillation
    Ischemia_Reperfusion_Injury --> Post_Infarction_Inflammation_and_Cardiac_Repair
    Post_Infarction_Inflammation_and_Cardiac_Repair --> Cardiac_Fibrosis_and_Ventricular_Remodeling
    Cardiac_Fibrosis_and_Ventricular_Remodeling --> Reduced_left_ventricular_ejection_fraction
    Cardiac_Fibrosis_and_Ventricular_Remodeling --> Congestive_heart_failure
    Arrhythmia --> Ventricular_fibrillation
    Arrhythmia --> Syncope
    Reduced_left_ventricular_ejection_fraction --> Dyspnea
    Coronary_Reperfusion_PCI_or_Fibrinolysis --> Coronary_Atherothrombosis
    Coronary_Reperfusion_PCI_or_Fibrinolysis --> Myocardial_Ischemia_and_Cardiomyocyte_Death
    Antiplatelet_and_Antithrombotic_Therapy --> Coronary_Atherothrombosis
    Anti_Inflammatory___Immunomodulatory_Therapy --> Post_Infarction_Inflammation_and_Cardiac_Repair
    Anti_Inflammatory___Immunomodulatory_Therapy --> Ischemia_Reperfusion_Injury
    Human_cardiac_infarct_organoid_with_an_internal_oxygen_diffusion_gradient --> Myocardial_Ischemia_and_Cardiomyocyte_Death
    Human_cardiac_infarct_organoid_with_an_internal_oxygen_diffusion_gradient --> Cardiac_Fibrosis_and_Ventricular_Remodeling
    Myocardial_infarct_border_zone_on_a_chip --> Myocardial_Ischemia_and_Cardiomyocyte_Death
    Myocardial_infarct_border_zone_on_a_chip --> Post_Infarction_Inflammation_and_Cardiac_Repair
    Human_heart_on_a_chip_ischemia_reperfusion_assay_with_endothelial_extracellular_vesicle_rescue --> Ischemia_Reperfusion_Injury
    Bioelectronically_instrumented_heart_on_a_chip_under_acute_hypoxia --> Myocardial_Ischemia_and_Cardiomyocyte_Death
    Epicardial_myocardial_heart_on_a_chip_model_of_ischemia_reperfusion_injury --> Ischemia_Reperfusion_Injury
    Epicardial_myocardial_heart_on_a_chip_model_of_ischemia_reperfusion_injury --> Cardiac_Fibrosis_and_Ventricular_Remodeling
    Myocardial_Ischemia_and_Cardiomyocyte_Death -.-> Elevated_cardiac_troponin
    Myocardial_Ischemia_and_Cardiomyocyte_Death -.-> Elevated_CK_MB
    Coronary_Atherothrombosis -.-> Total_lipids_in_very_small_VLDL_XS_VLDL_L
    Coronary_Atherothrombosis -.-> Phospholipids_to_total_lipids_in_small_HDL_percent_S_HDL_PL%

    style Coronary_Atherothrombosis fill:#dbeafe
    style Arrhythmia fill:#fef3c7
    style Chest_pain fill:#fef3c7
    style Anti_Inflammatory___Immunomodulatory_Therapy fill:#fce7f3
    style Myocardial_Ischemia_and_Cardiomyocyte_Death fill:#dbeafe
    style Human_heart_on_a_chip_ischemia_reperfusion_assay_with_endothelial_extracellular_vesicle_rescue fill:#ccfbf1
    style Epicardial_myocardial_heart_on_a_chip_model_of_ischemia_reperfusion_injury fill:#ccfbf1
    style Cardiac_Fibrosis_and_Ventricular_Remodeling fill:#dbeafe
    style Elevated_cardiac_troponin fill:#e0e7ff
    style Post_Infarction_Inflammation_and_Cardiac_Repair fill:#dbeafe
    style Congestive_heart_failure fill:#fef3c7
    style Syncope fill:#fef3c7
    style Reduced_left_ventricular_ejection_fraction fill:#fef3c7
    style Dyspnea fill:#fef3c7
    style Bioelectronically_instrumented_heart_on_a_chip_under_acute_hypoxia fill:#ccfbf1
    style Total_lipids_in_very_small_VLDL_XS_VLDL_L fill:#e0e7ff
    style Coronary_Reperfusion_PCI_or_Fibrinolysis fill:#fce7f3
    style Elevated_CK_MB fill:#e0e7ff
    style Myocardial_infarct_border_zone_on_a_chip fill:#ccfbf1
    style Myocardial_infarction fill:#fef3c7
    style Angina_pectoris fill:#fef3c7
    style Human_cardiac_infarct_organoid_with_an_internal_oxygen_diffusion_gradient fill:#ccfbf1
    style Ventricular_fibrillation fill:#fef3c7
    style Antiplatelet_and_Antithrombotic_Therapy fill:#fce7f3
    style Phospholipids_to_total_lipids_in_small_HDL_percent_S_HDL_PL% fill:#e0e7ff
    style Ischemia_Reperfusion_Injury fill:#dbeafe