NIH Highlighted Funding Topic Classification

Secondary, non-primary classification tagging a disease entry or curation project with the NIH "Highlighted Topics" funding-priority area(s) it is relevant to. This captures grant-strategy relevance, NOT disease nosology, so an entry may carry several tags or none. The topics are transient (each expires ~2 years after posting); this enum is GENERATED from a dated snapshot (2026-07-12) by scripts/gen_nih_topics_enum.py -- do not hand-edit.

Schema enum: NIHResearchPriorityEnum Schema source: https://w3id.org/monarch-initiative/dismech/classifications/nih_research_priorities

Schema Enum Description

NIH Highlighted Topics funding-priority areas. Tag entries/projects with the topic(s) whose research goals they advance. Snapshot: 2026-07-12.

NIH_HT_2_transition_from_pediatric_to_adult_health

Research on the Transition from Pediatric to Adult Health Care (NIH Highlighted Topic 2; expires August 29, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/2
NIH_HT_3_prevention_treatment_bacterial_sexually_transmitted_infections

Advancing Prevention and Treatment of Bacterial Sexually Transmitted Infections in HIV-Affected Populations (NIH Highlighted Topic 3; expires September 11, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/3
NIH_HT_4_impact_immune_function_neurocognition_substance_use

Understanding the Impact of Immune Function on Neurocognition and Substance Use Disorder Risk Across the Lifespan (IMMUNE-LIFESPAN) (NIH Highlighted Topic 4; expires September 10, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/4
NIH_HT_5_sleep_circadian_rhythms_substance_use_disorders

Sleep, Circadian Rhythms, and Substance Use Disorders (NIH Highlighted Topic 5; expires September 10, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/5
NIH_HT_6_novel_targets_methods_pharmacological_approaches_to

Novel Targets, Methods, and Pharmacological Approaches to Treat Substance Use Disorder (NIH Highlighted Topic 6; expires January 28, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/6
NIH_HT_7_novel_circuits_mechanisms_modulating_sensory_integration

Novel Circuits and Mechanisms Modulating Sensory Integration and Addiction (NIH Highlighted Topic 7; expires January 9, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/7
NIH_HT_8_data_science_artificial_intelligence_approaches_biomedical

Data Science and Artificial Intelligence Approaches for Biomedical, Biobehavioral and Social Science Research (NIH Highlighted Topic 8; expires June 25, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/8
NIH_HT_9_drowning_prevention

Research on Drowning Prevention (NIH Highlighted Topic 9; expires August 29, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/9
NIH_HT_10_effects_contraception_as_treatment_gynecologic_disorders

Effects of Contraception as Treatment for Gynecologic Disorders (NIH Highlighted Topic 10; expires August 29, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/10
NIH_HT_11_school_mental_behavioral_health_expanding_access

School Mental and Behavioral Health: Expanding Access to Evidence-Based Interventions and Services (NIH Highlighted Topic 11; expires September 11, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/11
NIH_HT_12_computational_approaches_in_fundamental_neuroscience

Computational Approaches in Fundamental Neuroscience (NIH Highlighted Topic 12; expires January 27, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/12
NIH_HT_13_combating_chronic_disease_burden_role_trauma

Understanding and Combating Chronic Disease Burden: The Role of Trauma (NIH Highlighted Topic 13; expires September 10, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/13
NIH_HT_16_priority_questions_in_fundamental_cellular_molecular

Priority Research Questions in Fundamental Cellular and Molecular Neuroscience (NIH Highlighted Topic 16; expires September 15, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/16
NIH_HT_18_brain_initiative_data_knowledgebase_ecosystem_neuroai

BRAIN Initiative: Data Knowledgebase Ecosystem and NeuroAI Integration (NIH Highlighted Topic 18; expires September 29, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/18
NIH_HT_19_brain_initiative_human_neuroscience_precision_molecular

BRAIN Initiative: Advancing Human Neuroscience and Precision Molecular Therapies for Transformative Treatments (NIH Highlighted Topic 19; expires January 22, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/19
NIH_HT_20_implementation_science_to_optimize_hiv_prevention

Implementation Science to Optimize HIV Prevention and Treatment (NIH Highlighted Topic 20; expires December 2, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/20
NIH_HT_21_microbiome_science_through_multidisciplinary_mechanistic_investigations

Advancing Microbiome Science Through Multidisciplinary Mechanistic Investigations of the Human Microbiome in Health and Disease (NIH Highlighted Topic 21; expires January 15, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/21
NIH_HT_22_short_lived_long_lived_plasma_cells

Research on Short-Lived and Long-Lived Plasma Cells in Humans (NIH Highlighted Topic 22; expires September 10, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/22
NIH_HT_23_in_celiac_disease

Accelerating Research in Celiac Disease (NIH Highlighted Topic 23; expires September 10, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/23
NIH_HT_24_computational_modeling_complex_processes_across_biological

Computational Modeling of Complex Processes Across Biological Scales (NIH Highlighted Topic 24; expires April 17, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/24
NIH_HT_25_neural_exposome_factors_that_affect_brain

Neural Exposome Factors that Affect Brain Health and Neurological Disorders (NIH Highlighted Topic 25; expires December 2, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/25
NIH_HT_27_technology_development_genomics

Technology Development for Genomics (NIH Highlighted Topic 27; expires August 29, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/27
NIH_HT_28_use_genomic_information_clinical_care

Advancing the Use of Genomic Information Into Clinical Care (NIH Highlighted Topic 28; expires August 29, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/28
NIH_HT_31_resources_from_osteoarthritis_initiative_oai

Supporting Research Using the Resources from the Osteoarthritis Initiative (OAI) (NIH Highlighted Topic 31; expires January 26, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/31
NIH_HT_33_training_career_development_in_dissemination_implementation

Training and Career Development in Dissemination and Implementation Science (NIH Highlighted Topic 33; expires April 14, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/33
NIH_HT_34_evaluating_evidence_based_practice_users_augmentative

Developing and Evaluating Evidence-Based Practice for Users of Augmentative and Alternative Communication (AAC) (NIH Highlighted Topic 34; expires January 26, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/34
NIH_HT_35_use_3d_technologies_human_auditory_vestibular

Advancing the Use of 3D Technologies Using Human Auditory, Vestibular and Chemosensory Organoids to Create New Approach Models (NAMs) for Treatments (NIH Highlighted Topic 35; expires December 2, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/35
NIH_HT_36_meaningful_outcome_measures_in_adult_hearing

Advancing Meaningful Outcome Measures in Adult Hearing Care (NIH Highlighted Topic 36; expires December 8, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/36
NIH_HT_37_fundamental_science_neural_circuits_underlying_sensory

Fundamental Science Research on the Neural Circuits Underlying Sensory Processing (NIH Highlighted Topic 37; expires January 22, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/37
NIH_HT_38_leveraging_new_approach_methodologies_non_animal

Leveraging New Approach Methodologies and Non-Animal Technologies to Accelerate Osteoarthritis Research (NIH Highlighted Topic 38; expires August 29, 2027). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/38
NIH_HT_42_rare_cancers_across_cancer_control_continuum
Research on Rare Cancers Across the Cancer Control Continuum (NIH Highlighted Topic 42; expires February 20, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/42

Tagged Disorders
NIH_HT_43_autoimmune_disease_integrating_genetic_environmental_immunological

Advancing Autoimmune Disease Research: Integrating Genetic, Environmental, and Immunological Factors to Improve Diagnosis and Treatment (NIH Highlighted Topic 43; expires February 12, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/43
NIH_HT_45_optimal_interprofessional_teaming_care_coordination_strategies

Optimal Interprofessional Teaming and Care Coordination Strategies for Cancer Care Quality and Outcomes (NIH Highlighted Topic 45; expires February 13, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/45
NIH_HT_46_drug_discovery_nervous_system_disorders

Drug Discovery for Nervous System Disorders (NIH Highlighted Topic 46; expires January 28, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/46
NIH_HT_48_nutrition_to_inform_regulatory_practice

Advancing Nutrition Research to Inform Regulatory Practice (NIH Highlighted Topic 48; expires March 20, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/48
NIH_HT_49_science_prenatal_dietary_supplements

Advancing the Science of Prenatal Dietary Supplements (NIH Highlighted Topic 49; expires May 21, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/49
NIH_HT_50_nanotechnology_to_improve_diagnosis_treatment_options

Advancing Nanotechnology Research to Improve Diagnosis and Treatment Options (NIH Highlighted Topic 50; expires March 10, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/50
NIH_HT_51_treatment_options_targeted_degrader_technologies

Advancing Treatment Options using Targeted Degrader Technologies (NIH Highlighted Topic 51; expires March 10, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/51
NIH_HT_52_biomedical_promoting_trust_improving_health_through

Strengthening Biomedical Research, Promoting Trust, and Improving Health through Bioethics Research (NIH Highlighted Topic 52; expires January 12, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/52
NIH_HT_53_multidisciplinary_studies_hiv_aids_aging

Multidisciplinary Studies of HIV/AIDS and Aging (NIH Highlighted Topic 53; expires March 20, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/53
NIH_HT_54_science_science_to_understand_strengthen_biomedical

Advancing "Science of Science" Research to Understand and Strengthen the Biomedical Research Ecosystem (NIH Highlighted Topic 54; expires March 31, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/54
NIH_HT_55_mechanism_driven_translational_beneficial_detrimental_effect

Advancing Mechanism-driven Translational Research of Beneficial and Detrimental Effect of Psilocybin on Cancer and Other Health Conditions (NIH Highlighted Topic 55; expires April 10, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/55
NIH_HT_56_characterizing_interactions_between_biology_electromagnetic_radiation

Characterizing Interactions between Biology and Electromagnetic Radiation (NIH Highlighted Topic 56; expires April 20, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/56
NIH_HT_57_quantum_information_science_technologies_biomedical_applications

Quantum Information Science & Technologies for Biomedical Applications (NIH Highlighted Topic 57; expires April 9, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/57
NIH_HT_58_nutritional_influences_neurodevelopmental_disorders_in_children

Understanding Nutritional Influences on Neurodevelopmental Disorders in Children (NIH Highlighted Topic 58; expires March 10, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/58
NIH_HT_59_otitis_media_workforce_development

Accelerating Otitis Media Research and Workforce Development (NIH Highlighted Topic 59; expires May 26, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/59
NIH_HT_60_glp_1s_implications_nutritional_status_metabolic

GLP-1s: Implications for Nutritional Status and Metabolic Health Outcomes (NIH Highlighted Topic 60; expires April 24, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/60
NIH_HT_61_hidradenitis_suppurativa

Accelerating Hidradenitis Suppurativa Research (NIH Highlighted Topic 61; expires April 7, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/61
NIH_HT_62_new_approach_methodologies_nams_dietary_supplement

New Approach Methodologies (NAMs) for Dietary Supplement and Nutrition research (NIH Highlighted Topic 62; expires May 20, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/62
NIH_HT_66_scientific_rigor_transparency_replicability

Enhancing Scientific Rigor, Transparency and Replicability (NIH Highlighted Topic 66; expires April 27, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/66
NIH_HT_67_cause_treatment_rare_skin_diseases

Advancing Research into the Cause and Treatment of Rare Skin Diseases (NIH Highlighted Topic 67; expires April 2, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/67
NIH_HT_68_childhood_adolescent_young_adult_aya_cancer
Advancing Childhood and Adolescent & Young Adult (AYA) Cancer Research (NIH Highlighted Topic 68; expires April 15, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/68

Tagged Disorders
NIH_HT_69_health_extreme_weather_critical_to_address

Health and Extreme Weather: Advancing Critical Research to Address the Direct and Indirect Health Impacts of Weather-Related Natural Disasters and Emerging Weather-Related Harms (NIH Highlighted Topic 69; expires May 1, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/69
NIH_HT_70_chatbots_their_usage

Research on Chatbots and their Usage (NIH Highlighted Topic 70; expires April 15, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/70
NIH_HT_71_tackling_acquisition_language_in_kids_talk

Tackling Acquisition of Language in Kids (TALK) (NIH Highlighted Topic 71; expires April 21, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/71
NIH_HT_72_cure_acquired_neuropathy

Advancing Toward a Cure for Acquired Neuropathy (NIH Highlighted Topic 72; expires April 6, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/72
NIH_HT_73_behavioral_cognitive_signals_aging_in_real

Behavioral and Cognitive Signals of Aging in Real-World Contexts (NIH Highlighted Topic 73; expires June 24, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/73
NIH_HT_74_oral_health_aging

Oral Health and Aging (NIH Highlighted Topic 74; expires June 5, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/74
NIH_HT_76_role_post_translational_modifications_in_human

Research on the Role of Post-Translational Modifications in Human Health and Disease (NIH Highlighted Topic 76; expires June 26, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/76
NIH_HT_78_food_is_medicine

Food Is Medicine (NIH Highlighted Topic 78; expires June 3, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/78
NIH_HT_79_data_usage_utility_to_advance_biomedical

Enhancing Data Usage and Utility to Advance Biomedical Research (NIH Highlighted Topic 79; expires June 24, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/79
NIH_HT_82_breaking_barriers_integrating_immunology_neuroscience_to

Breaking Barriers: Integrating Immunology and Neuroscience to Transform AD/ADRD Research and Bring a Better Understanding of the Aging Brain (NIH Highlighted Topic 82; expires May 1, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/82
NIH_HT_83_biology_physics_informed_explainable_ai_across

Biology- and Physics-Informed Explainable AI Across the Lifespan (NIH Highlighted Topic 83; expires June 2, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/83
NIH_HT_84_postnatal_human_developmental_stages_transitions_relationships

Postnatal Human Developmental Stages and Transitions: Relationships to Aging Changes and Outcomes over the Life Course (NIH Highlighted Topic 84; expires May 22, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/84
NIH_HT_85_improve_funded_maternal_health_centers_excellence

Enhancing the IMPROVE-funded Maternal Health Centers of Excellence (NIH Highlighted Topic 85; expires April 7, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/85
NIH_HT_86_biomarker_discovery_validation_alcohol_related_cardiovascular

Biomarker Discovery and Validation for Alcohol-Related Cardiovascular Diseases (NIH Highlighted Topic 86; expires May 22, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/86
NIH_HT_88_unexplained_anemia_in_older_persons_elucidating

Unexplained Anemia in Older Persons: Elucidating Etiologies, Improving Diagnoses, and Identifying and Testing Potential Treatment Strategies (NIH Highlighted Topic 88; expires May 11, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/88
NIH_HT_89_cellular_quiescence_senescence_cell_death_in
Cellular Quiescence, Senescence, and Cell Death in Aging and Disease (NIH Highlighted Topic 89; expires July 1, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/89

Tagged Disorders
NIH_HT_90_integrating_environmental_science_engineering_with_biomedical

Integrating Environmental Science and Engineering with Biomedical Research for Effective Exposure Prevention and Disease Intervention (NIH Highlighted Topic 90; expires June 18, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/90
NIH_HT_93_implementation_science_to_optimize_alcohol_misuse

Implementation Science to Optimize Alcohol Misuse Prevention and Treatment in the Criminal Justice System (NIH Highlighted Topic 93; expires July 7, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/93
NIH_HT_94_increasing_engagement_in_treatment_behavioral_health

Increasing Engagement in Treatment for Behavioral Health (NIH Highlighted Topic 94; expires July 8, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/94
NIH_HT_95_rna_metabolism_in_aging_healthy_lifespan

RNA Metabolism in Aging and Healthy Lifespan (NIH Highlighted Topic 95; expires July 10, 2028). https://grants.nih.gov/funding/find-a-fit-for-your-research/highlighted-topics/95