Class: TreatmentMechanismTarget

Links a treatment to a specific pathophysiology mechanism node it targets. Enables reasoning about which downstream phenotypes should respond to therapy and why resistance may emerge when the causal chain shifts.

URI: dismech:TreatmentMechanismTarget

 classDiagram
    class TreatmentMechanismTarget
    click TreatmentMechanismTarget href "../TreatmentMechanismTarget/"
      TreatmentMechanismTarget : description

      TreatmentMechanismTarget : evidence





        TreatmentMechanismTarget --> "*" EvidenceItem : evidence
        click EvidenceItem href "../EvidenceItem/"



      TreatmentMechanismTarget : target

      TreatmentMechanismTarget : treatment_effect





        TreatmentMechanismTarget --> "0..1" TreatmentEffectEnum : treatment_effect
        click TreatmentEffectEnum href "../TreatmentEffectEnum/"

Slots

Name	Cardinality and Range	Description	Inheritance
target	1 String	Name of the pathophysiology entry this treatment targets	direct
treatment_effect	0..1 TreatmentEffectEnum	How the treatment affects the targeted mechanism	direct
description	0..1 String		direct
evidence	* recommended EvidenceItem	Evidence that this treatment targets this specific mechanism	direct

Usages

used by	used in	type	used
Treatment	target_mechanisms	range	TreatmentMechanismTarget

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type	Mapped Value
self	dismech:TreatmentMechanismTarget
native	dismech:TreatmentMechanismTarget

LinkML Source

Direct

name: TreatmentMechanismTarget
description: Links a treatment to a specific pathophysiology mechanism node it targets.
  Enables reasoning about which downstream phenotypes should respond to therapy and
  why resistance may emerge when the causal chain shifts.
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- target
- treatment_effect
- description
- evidence
slot_usage:
  target:
    name: target
    description: Name of the pathophysiology entry this treatment targets. Must match
      a pathophysiology name in the same disease file.
  evidence:
    name: evidence
    description: Evidence that this treatment targets this specific mechanism

Induced

name: TreatmentMechanismTarget
description: Links a treatment to a specific pathophysiology mechanism node it targets.
  Enables reasoning about which downstream phenotypes should respond to therapy and
  why resistance may emerge when the causal chain shifts.
from_schema: https://w3id.org/monarch-initiative/dismech
slot_usage:
  target:
    name: target
    description: Name of the pathophysiology entry this treatment targets. Must match
      a pathophysiology name in the same disease file.
  evidence:
    name: evidence
    description: Evidence that this treatment targets this specific mechanism
attributes:
  target:
    name: target
    description: Name of the pathophysiology entry this treatment targets. Must match
      a pathophysiology name in the same disease file.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: target
    owner: TreatmentMechanismTarget
    domain_of:
    - CausalEdge
    - TreatmentMechanismTarget
    range: string
    required: true
  treatment_effect:
    name: treatment_effect
    description: How the treatment affects the targeted mechanism
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: treatment_effect
    owner: TreatmentMechanismTarget
    domain_of:
    - TreatmentMechanismTarget
    range: TreatmentEffectEnum
  description:
    name: description
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: description
    owner: TreatmentMechanismTarget
    domain_of:
    - Descriptor
    - GeneticContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - HistopathologyFinding
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - FunctionalEffect
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ConditionDescriptor
    - GOEnrichment
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    range: string
  evidence:
    name: evidence
    description: Evidence that this treatment targets this specific mechanism
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: evidence
    owner: TreatmentMechanismTarget
    domain_of:
    - PhenotypeContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - Finding
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Diagnosis
    - Inheritance
    - Variant
    - ModelingConsideration
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - AssociationSignal
    - AssociationStatistics
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    range: EvidenceItem
    recommended: true
    multivalued: true
    inlined: true
    inlined_as_list: true