Class: MechanisticHypothesis

Disease-level hypothesis metadata used to organize downstream causal edges into canonical or alternative explanatory models.

URI: dismech:MechanisticHypothesis

 classDiagram
    class MechanisticHypothesis
    click MechanisticHypothesis href "../MechanisticHypothesis/"
      MechanisticHypothesis : applies_to_subtypes

      MechanisticHypothesis : description

      MechanisticHypothesis : evidence





        MechanisticHypothesis --> "*" EvidenceItem : evidence
        click EvidenceItem href "../EvidenceItem/"



      MechanisticHypothesis : hypothesis_group_id

      MechanisticHypothesis : hypothesis_label

      MechanisticHypothesis : notes

      MechanisticHypothesis : status





        MechanisticHypothesis --> "0..1" MechanisticHypothesisStatusEnum : status
        click MechanisticHypothesisStatusEnum href "../MechanisticHypothesisStatusEnum/"

Slots

Name	Cardinality and Range	Description	Inheritance
hypothesis_group_id	1 String	Stable identifier for a disease-level mechanistic hypothesis grouping	direct
hypothesis_label	0..1 String	Human-readable label/title for a mechanistic hypothesis	direct
status	0..1 MechanisticHypothesisStatusEnum	Status or state of a clinical trial or other process	direct
description	0..1 String		direct
applies_to_subtypes	* String	Disease subtypes for which this hypothesis is intended to apply	direct
evidence	* recommended EvidenceItem		direct
notes	0..1 String		direct

Usages

used by	used in	type	used
Disease	mechanistic_hypotheses	range	MechanisticHypothesis

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type	Mapped Value
self	dismech:MechanisticHypothesis
native	dismech:MechanisticHypothesis

LinkML Source

Direct

name: MechanisticHypothesis
description: Disease-level hypothesis metadata used to organize downstream causal
  edges into canonical or alternative explanatory models.
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- hypothesis_group_id
- hypothesis_label
- status
- description
- applies_to_subtypes
- evidence
- notes
slot_usage:
  hypothesis_group_id:
    name: hypothesis_group_id
    required: true
  status:
    name: status
    range: MechanisticHypothesisStatusEnum

Induced

name: MechanisticHypothesis
description: Disease-level hypothesis metadata used to organize downstream causal
  edges into canonical or alternative explanatory models.
from_schema: https://w3id.org/monarch-initiative/dismech
slot_usage:
  hypothesis_group_id:
    name: hypothesis_group_id
    required: true
  status:
    name: status
    range: MechanisticHypothesisStatusEnum
attributes:
  hypothesis_group_id:
    name: hypothesis_group_id
    description: Stable identifier for a disease-level mechanistic hypothesis grouping
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: hypothesis_group_id
    owner: MechanisticHypothesis
    domain_of:
    - MechanisticHypothesis
    range: string
    required: true
  hypothesis_label:
    name: hypothesis_label
    description: Human-readable label/title for a mechanistic hypothesis
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: hypothesis_label
    owner: MechanisticHypothesis
    domain_of:
    - MechanisticHypothesis
    range: string
  status:
    name: status
    description: Status or state of a clinical trial or other process
    examples:
    - value: Recruiting
    - value: Completed
    - value: Terminated
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: status
    owner: MechanisticHypothesis
    domain_of:
    - ClinicalTrial
    - MechanisticHypothesis
    range: MechanisticHypothesisStatusEnum
  description:
    name: description
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: description
    owner: MechanisticHypothesis
    domain_of:
    - Descriptor
    - GeneticContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - HistopathologyFinding
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - FunctionalEffect
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ConditionDescriptor
    - GOEnrichment
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    range: string
  applies_to_subtypes:
    name: applies_to_subtypes
    description: Disease subtypes for which this hypothesis is intended to apply
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: applies_to_subtypes
    owner: MechanisticHypothesis
    domain_of:
    - MechanisticHypothesis
    range: string
    multivalued: true
  evidence:
    name: evidence
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: evidence
    owner: MechanisticHypothesis
    domain_of:
    - PhenotypeContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - Finding
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Diagnosis
    - Inheritance
    - Variant
    - ModelingConsideration
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - AssociationSignal
    - AssociationStatistics
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    range: EvidenceItem
    recommended: true
    multivalued: true
    inlined: true
    inlined_as_list: true
  notes:
    name: notes
    examples:
    - value: Contagious stage where symptoms appear and the bacteria can be spread
        to others.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: notes
    owner: MechanisticHypothesis
    domain_of:
    - GeneticContext
    - OnsetDescriptor
    - PhenotypeContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - Treatment
    - Transmission
    - Diagnosis
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - TermMapping
    - MappingConsistency
    - ComorbidityAssociation
    - AssociationSignal
    - AssociationMetric
    - AssociationStatistics
    - MechanisticHypothesis
    range: string