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Enum: HarrisonsChapterEnum

Traditional internal medicine chapter groupings for disease classification. Based on Harrison's Principles of Internal Medicine organization. Sub-chapters use is_a to indicate parent category.

URI: dismech:HarrisonsChapterEnum

Permissible Values

Value Meaning Description
cardiovascular disorder MONDO:0004995 Heart and vascular diseases, including ischemic, structural, rhythm, and vasc...
coronary artery disorder MONDO:0005010 Ischemic heart disease due to coronary artery pathology; includes myocardial ...
cardiomyopathy MONDO:0004994 Primary diseases of the myocardium affecting systolic or diastolic function
cardiac rhythm disease MONDO:0007263 Electrical conduction or rhythm disorders causing arrhythmias or heart block
valvular heart disease MONDO:0002869 Structural or functional valve disease (stenosis or regurgitation) affecting ...
vascular disease MONDO:0005385 Arterial or venous disorders such as aneurysm, peripheral artery disease, or ...
respiratory system disorder MONDO:0005087 Diseases of airways, lung parenchyma, and pleura that impair ventilation or g...
obstructive lung disease MONDO:0002267 Airflow limitation from airway narrowing or collapse, including COPD and asth...
interstitial lung disease MONDO:0015925 Diffuse parenchymal lung disorders with inflammation or fibrosis that reduce ...
pulmonary vascular disease None Pulmonary arterial or venous vascular disorders, including hypertension and e...
digestive system disorder MONDO:0004335 Diseases of the gastrointestinal tract and accessory organs affecting digesti...
inflammatory bowel disease MONDO:0005265 Chronic immune-mediated intestinal inflammation, typically Crohn disease or u...
peptic disorder MONDO:0004247 Acid-related disorders of the esophagus, stomach, or duodenum such as GERD an...
liver disorder MONDO:0005154 Hepatobiliary diseases involving liver parenchyma, bile ducts, or gallbladder
kidney disorder MONDO:0005240 Renal and urinary tract diseases affecting filtration, electrolyte balance, o...
glomerular disease MONDO:0019722 Diseases of the glomerulus causing hematuria, proteinuria, or nephrotic/nephr...
hematologic disorder MONDO:0005570 Disorders of blood cells, bone marrow, and hemostasis
anemia MONDO:0002280 Reduced red cell mass or hemoglobin due to production defects, blood loss, or...
coagulation disorder MONDO:0001531 Bleeding or thrombotic disorders from clotting factor, platelet, or regulator...
cancer MONDO:0004992 Neoplastic diseases characterized by uncontrolled cell proliferation and inva...
hematologic malignancy MONDO:0002334 Cancers of blood, bone marrow, and lymphoid tissues such as leukemia or lymph...
solid tumor None Non-hematologic neoplasms arising in organs or soft tissues
infectious disease MONDO:0005550 Illness caused by pathogenic organisms with host invasion and immune response
bacterial infectious disease MONDO:0005113 Infections caused by bacteria, including community and healthcare-associated ...
viral infectious disease MONDO:0005108 Infections caused by viruses affecting any organ system
fungal infectious disease MONDO:0002041 Mycoses ranging from superficial to invasive systemic infections
parasitic infectious disease MONDO:0005135 Protozoal or helminth infections, often vector-borne or food/water transmitte...
mycobacterial infection MONDO:0020590 Infections due to Mycobacterium species, including tuberculosis and non-tuber...
immune system disorder MONDO:0005046 Immune dysregulation disorders including autoimmunity, immunodeficiency, or h...
autoimmune disease MONDO:0007179 Immune-mediated tissue damage due to loss of self-tolerance
allergic disease MONDO:0005271 Hypersensitivity disorders including atopy, allergic asthma, and anaphylaxis
endocrine system disorder MONDO:0005151 Hormonal and metabolic gland disorders affecting systemic homeostasis
diabetes mellitus MONDO:0005015 Disorders of glucose regulation due to insulin deficiency and/or insulin resi...
thyroid disorder MONDO:0003240 Thyroid gland dysfunction or structural disease altering metabolic control
adrenal disorder MONDO:0005495 Adrenal cortex or medulla disorders causing hormone excess or deficiency
nervous system disorder MONDO:0005071 Central or peripheral nervous system diseases affecting cognition, sensation,...
cerebrovascular disorder MONDO:0011057 Brain ischemia or hemorrhage due to vascular disease, including stroke and TI...
neurodegenerative disease MONDO:0005559 Progressive neuronal loss leading to cognitive or motor decline
demyelinating disease MONDO:0002562 Disorders with loss of myelin in the nervous system, often immune-mediated
neuromuscular disease MONDO:0019056 Diseases of peripheral nerve, neuromuscular junction, or muscle leading to we...
epilepsy MONDO:0005027 Recurrent unprovoked seizures from abnormal neuronal activity
movement disorder MONDO:0005395 Motor control disorders causing tremor, rigidity, dystonia, chorea, or ataxia
musculoskeletal system disorder MONDO:0002081 Diseases of joints, bones, muscles, or connective tissue
inflammatory arthritis None Inflammatory joint disorders with synovitis, such as RA or spondyloarthropath...
connective tissue disease MONDO:0003900 Systemic autoimmune connective tissue disorders affecting skin, joints, vesse...
skin disorder MONDO:0005093 Diseases of the skin, hair, nails, and related appendages
psychiatric disorder MONDO:0002025 Mental and behavioral disorders affecting mood, thought, or behavior
hereditary disease MONDO:0003847 Genetic or congenital disorders due to inherited variants or developmental an...

Slots

Name Description
classification_value

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: HarrisonsChapterEnum
description: Traditional internal medicine chapter groupings for disease classification.
  Based on Harrison's Principles of Internal Medicine organization. Sub-chapters use
  is_a to indicate parent category.
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  cardiovascular disorder:
    text: cardiovascular disorder
    description: Heart and vascular diseases, including ischemic, structural, rhythm,
      and vascular conditions.
    meaning: MONDO:0004995
    title: Diseases of the heart and blood vessels
  coronary artery disorder:
    text: coronary artery disorder
    description: Ischemic heart disease due to coronary artery pathology; includes
      myocardial infarction and angina.
    meaning: MONDO:0005010
    is_a: cardiovascular disorder
    title: Ischemic heart disease, myocardial infarction, angina
  cardiomyopathy:
    text: cardiomyopathy
    description: Primary diseases of the myocardium affecting systolic or diastolic
      function.
    meaning: MONDO:0004994
    is_a: cardiovascular disorder
    title: Diseases of heart muscle (dilated, hypertrophic, restrictive)
  cardiac rhythm disease:
    text: cardiac rhythm disease
    description: Electrical conduction or rhythm disorders causing arrhythmias or
      heart block.
    meaning: MONDO:0007263
    is_a: cardiovascular disorder
    title: Arrhythmias, conduction disorders
  valvular heart disease:
    text: valvular heart disease
    description: Structural or functional valve disease (stenosis or regurgitation)
      affecting cardiac hemodynamics.
    meaning: MONDO:0002869
    is_a: cardiovascular disorder
    title: Diseases of heart valves (stenosis, regurgitation)
  vascular disease:
    text: vascular disease
    description: Arterial or venous disorders such as aneurysm, peripheral artery
      disease, or thrombosis.
    meaning: MONDO:0005385
    is_a: cardiovascular disorder
    title: Diseases of arteries and veins (aneurysm, PAD, DVT)
  respiratory system disorder:
    text: respiratory system disorder
    description: Diseases of airways, lung parenchyma, and pleura that impair ventilation
      or gas exchange.
    meaning: MONDO:0005087
    title: Diseases of the lungs and airways
  obstructive lung disease:
    text: obstructive lung disease
    description: Airflow limitation from airway narrowing or collapse, including COPD
      and asthma.
    meaning: MONDO:0002267
    is_a: respiratory system disorder
    title: COPD, asthma, bronchiectasis
  interstitial lung disease:
    text: interstitial lung disease
    description: Diffuse parenchymal lung disorders with inflammation or fibrosis
      that reduce gas exchange.
    meaning: MONDO:0015925
    is_a: respiratory system disorder
    title: Pulmonary fibrosis, sarcoidosis
  pulmonary vascular disease:
    text: pulmonary vascular disease
    description: Pulmonary arterial or venous vascular disorders, including hypertension
      and embolism.
    is_a: respiratory system disorder
    title: Pulmonary hypertension, pulmonary embolism
  digestive system disorder:
    text: digestive system disorder
    description: Diseases of the gastrointestinal tract and accessory organs affecting
      digestion or absorption.
    meaning: MONDO:0004335
    title: Diseases of the digestive tract and accessory organs
  inflammatory bowel disease:
    text: inflammatory bowel disease
    description: Chronic immune-mediated intestinal inflammation, typically Crohn
      disease or ulcerative colitis.
    meaning: MONDO:0005265
    is_a: digestive system disorder
    title: Crohn's disease, ulcerative colitis
  peptic disorder:
    text: peptic disorder
    description: Acid-related disorders of the esophagus, stomach, or duodenum such
      as GERD and peptic ulcer disease.
    meaning: MONDO:0004247
    is_a: digestive system disorder
    title: Peptic ulcer, GERD, gastritis
  liver disorder:
    text: liver disorder
    description: Hepatobiliary diseases involving liver parenchyma, bile ducts, or
      gallbladder.
    meaning: MONDO:0005154
    title: Diseases of the liver, gallbladder, and biliary system
  kidney disorder:
    text: kidney disorder
    description: Renal and urinary tract diseases affecting filtration, electrolyte
      balance, or urine flow.
    meaning: MONDO:0005240
    title: Diseases of the kidneys and urinary system
  glomerular disease:
    text: glomerular disease
    description: Diseases of the glomerulus causing hematuria, proteinuria, or nephrotic/nephritic
      syndromes.
    meaning: MONDO:0019722
    is_a: kidney disorder
    title: Glomerulonephritis, nephrotic syndrome
  hematologic disorder:
    text: hematologic disorder
    description: Disorders of blood cells, bone marrow, and hemostasis.
    meaning: MONDO:0005570
    title: Diseases of blood and blood-forming organs
  anemia:
    text: anemia
    description: Reduced red cell mass or hemoglobin due to production defects, blood
      loss, or hemolysis.
    meaning: MONDO:0002280
    is_a: hematologic disorder
    title: Red blood cell disorders
  coagulation disorder:
    text: coagulation disorder
    description: Bleeding or thrombotic disorders from clotting factor, platelet,
      or regulatory defects.
    meaning: MONDO:0001531
    is_a: hematologic disorder
    title: Bleeding and thrombotic disorders
  cancer:
    text: cancer
    description: Neoplastic diseases characterized by uncontrolled cell proliferation
      and invasion.
    meaning: MONDO:0004992
    title: Neoplastic diseases and cancer
  hematologic malignancy:
    text: hematologic malignancy
    description: Cancers of blood, bone marrow, and lymphoid tissues such as leukemia
      or lymphoma.
    meaning: MONDO:0002334
    is_a: cancer
    title: Leukemia, lymphoma, myeloma
  solid tumor:
    text: solid tumor
    description: Non-hematologic neoplasms arising in organs or soft tissues.
    is_a: cancer
    title: Carcinomas, sarcomas, other solid neoplasms
  infectious disease:
    text: infectious disease
    description: Illness caused by pathogenic organisms with host invasion and immune
      response.
    meaning: MONDO:0005550
    title: Diseases caused by pathogenic microorganisms
  bacterial infectious disease:
    text: bacterial infectious disease
    description: Infections caused by bacteria, including community and healthcare-associated
      pathogens.
    meaning: MONDO:0005113
    is_a: infectious disease
    title: Infections caused by bacteria
  viral infectious disease:
    text: viral infectious disease
    description: Infections caused by viruses affecting any organ system.
    meaning: MONDO:0005108
    is_a: infectious disease
    title: Infections caused by viruses
  fungal infectious disease:
    text: fungal infectious disease
    description: Mycoses ranging from superficial to invasive systemic infections.
    meaning: MONDO:0002041
    is_a: infectious disease
    title: Infections caused by fungi
  parasitic infectious disease:
    text: parasitic infectious disease
    description: Protozoal or helminth infections, often vector-borne or food/water
      transmitted.
    meaning: MONDO:0005135
    is_a: infectious disease
    title: Infections caused by parasites (protozoa, helminths)
  mycobacterial infection:
    text: mycobacterial infection
    description: Infections due to Mycobacterium species, including tuberculosis and
      non-tuberculous mycobacteria.
    meaning: MONDO:0020590
    is_a: infectious disease
    title: Tuberculosis, NTM, leprosy
  immune system disorder:
    text: immune system disorder
    description: Immune dysregulation disorders including autoimmunity, immunodeficiency,
      or hypersensitivity.
    meaning: MONDO:0005046
    title: Diseases of the immune system including autoimmunity
  autoimmune disease:
    text: autoimmune disease
    description: Immune-mediated tissue damage due to loss of self-tolerance.
    meaning: MONDO:0007179
    is_a: immune system disorder
    title: Diseases caused by immune attack on self
  allergic disease:
    text: allergic disease
    description: Hypersensitivity disorders including atopy, allergic asthma, and
      anaphylaxis.
    meaning: MONDO:0005271
    is_a: immune system disorder
    title: Hypersensitivity disorders, anaphylaxis
  endocrine system disorder:
    text: endocrine system disorder
    description: Hormonal and metabolic gland disorders affecting systemic homeostasis.
    meaning: MONDO:0005151
    title: Diseases of hormonal and metabolic systems
  diabetes mellitus:
    text: diabetes mellitus
    description: Disorders of glucose regulation due to insulin deficiency and/or
      insulin resistance.
    meaning: MONDO:0005015
    is_a: endocrine system disorder
    title: Type 1, type 2, and other forms of diabetes
  thyroid disorder:
    text: thyroid disorder
    description: Thyroid gland dysfunction or structural disease altering metabolic
      control.
    meaning: MONDO:0003240
    is_a: endocrine system disorder
    title: Hyper/hypothyroidism, thyroid nodules, thyroid cancer
  adrenal disorder:
    text: adrenal disorder
    description: Adrenal cortex or medulla disorders causing hormone excess or deficiency.
    meaning: MONDO:0005495
    is_a: endocrine system disorder
    title: Cushing's, Addison's, pheochromocytoma
  nervous system disorder:
    text: nervous system disorder
    description: Central or peripheral nervous system diseases affecting cognition,
      sensation, or movement.
    meaning: MONDO:0005071
    title: Diseases of the central and peripheral nervous system
  cerebrovascular disorder:
    text: cerebrovascular disorder
    description: Brain ischemia or hemorrhage due to vascular disease, including stroke
      and TIA.
    meaning: MONDO:0011057
    is_a: nervous system disorder
    title: Stroke, TIA, vascular dementia
  neurodegenerative disease:
    text: neurodegenerative disease
    description: Progressive neuronal loss leading to cognitive or motor decline.
    meaning: MONDO:0005559
    is_a: nervous system disorder
    title: Alzheimer's, Parkinson's, ALS, Huntington's
  demyelinating disease:
    text: demyelinating disease
    description: Disorders with loss of myelin in the nervous system, often immune-mediated.
    meaning: MONDO:0002562
    is_a: nervous system disorder
    title: Multiple sclerosis, NMO, ADEM
  neuromuscular disease:
    text: neuromuscular disease
    description: Diseases of peripheral nerve, neuromuscular junction, or muscle leading
      to weakness.
    meaning: MONDO:0019056
    is_a: nervous system disorder
    title: Myopathies, neuropathies, NMJ disorders
  epilepsy:
    text: epilepsy
    description: Recurrent unprovoked seizures from abnormal neuronal activity.
    meaning: MONDO:0005027
    is_a: nervous system disorder
    title: Seizure disorders
  movement disorder:
    text: movement disorder
    description: Motor control disorders causing tremor, rigidity, dystonia, chorea,
      or ataxia.
    meaning: MONDO:0005395
    is_a: nervous system disorder
    title: Parkinsonism, dystonia, chorea, ataxia
  musculoskeletal system disorder:
    text: musculoskeletal system disorder
    description: Diseases of joints, bones, muscles, or connective tissue.
    meaning: MONDO:0002081
    title: Diseases of joints, connective tissue, and musculoskeletal system
  inflammatory arthritis:
    text: inflammatory arthritis
    description: Inflammatory joint disorders with synovitis, such as RA or spondyloarthropathies.
    is_a: musculoskeletal system disorder
    title: Rheumatoid arthritis, spondyloarthritis, gout
  connective tissue disease:
    text: connective tissue disease
    description: Systemic autoimmune connective tissue disorders affecting skin, joints,
      vessels, and organs.
    meaning: MONDO:0003900
    is_a: musculoskeletal system disorder
    title: SLE, scleroderma, Sjogren's, vasculitis
  skin disorder:
    text: skin disorder
    description: Diseases of the skin, hair, nails, and related appendages.
    meaning: MONDO:0005093
    title: Diseases of the skin and appendages
  psychiatric disorder:
    text: psychiatric disorder
    description: Mental and behavioral disorders affecting mood, thought, or behavior.
    meaning: MONDO:0002025
    title: Mental and behavioral disorders
  hereditary disease:
    text: hereditary disease
    description: Genetic or congenital disorders due to inherited variants or developmental
      anomalies.
    meaning: MONDO:0003847
    title: Inherited diseases and birth defects