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Class: ComorbidityAssociation

An association between two conditions, including directionality, evidence, and computational characterizations.

URI: dismech:ComorbidityAssociation

 classDiagram
    class ComorbidityAssociation
    click ComorbidityAssociation href "../ComorbidityAssociation/"
      ComorbidityAssociation : association_signals





        ComorbidityAssociation --> "*" AssociationSignal : association_signals
        click AssociationSignal href "../AssociationSignal/"



      ComorbidityAssociation : creation_date

      ComorbidityAssociation : curation_status





        ComorbidityAssociation --> "0..1" CurationStatusEnum : curation_status
        click CurationStatusEnum href "../CurationStatusEnum/"



      ComorbidityAssociation : directionality





        ComorbidityAssociation --> "0..1" ComorbidityDirectionEnum : directionality
        click ComorbidityDirectionEnum href "../ComorbidityDirectionEnum/"



      ComorbidityAssociation : disease_a





        ComorbidityAssociation --> "0..1" ConditionDescriptor : disease_a
        click ConditionDescriptor href "../ConditionDescriptor/"



      ComorbidityAssociation : disease_b





        ComorbidityAssociation --> "0..1" ConditionDescriptor : disease_b
        click ConditionDescriptor href "../ConditionDescriptor/"



      ComorbidityAssociation : hypotheses





        ComorbidityAssociation --> "*" ComorbidityHypothesis : hypotheses
        click ComorbidityHypothesis href "../ComorbidityHypothesis/"



      ComorbidityAssociation : literature_evidence





        ComorbidityAssociation --> "*" EvidenceItem : literature_evidence
        click EvidenceItem href "../EvidenceItem/"



      ComorbidityAssociation : name

      ComorbidityAssociation : notes

      ComorbidityAssociation : phenotypes





        ComorbidityAssociation --> "*" Phenotype : phenotypes
        click Phenotype href "../Phenotype/"



      ComorbidityAssociation : shared_upstream_hypotheses





        ComorbidityAssociation --> "*" UpstreamConditionHypothesis : shared_upstream_hypotheses
        click UpstreamConditionHypothesis href "../UpstreamConditionHypothesis/"



      ComorbidityAssociation : updated_date

Slots

Name Cardinality and Range Description Inheritance
name 1
String		 direct
creation_date 0..1 recommended
String		 Timestamp for initial creation of this comorbidity entry direct
updated_date 0..1 recommended
String		 Timestamp for the latest substantive update to this comorbidity entry direct
disease_a 0..1
ConditionDescriptor		 First disease in a comorbidity pair direct
disease_b 0..1
ConditionDescriptor		 Second disease in a comorbidity pair direct
directionality 0..1
ComorbidityDirectionEnum		 Direction of a comorbidity/trajectory association direct
association_signals *
AssociationSignal		 Association signals from EHR, registry, or computational sources direct
literature_evidence *
EvidenceItem		 Literature-based evidence items for this association direct
hypotheses *
ComorbidityHypothesis		 Mechanistic or causal hypotheses about the association direct
shared_upstream_hypotheses *
UpstreamConditionHypothesis		 Suspected upstream conditions that may explain both A and B direct
phenotypes *
Phenotype		 direct
notes 0..1
String		 direct
curation_status 0..1
CurationStatusEnum		 Curation workflow status direct

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type Mapped Value
self dismech:ComorbidityAssociation
native dismech:ComorbidityAssociation

LinkML Source

Direct

name: ComorbidityAssociation
description: An association between two conditions, including directionality, evidence,
  and computational characterizations.
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- name
- creation_date
- updated_date
- disease_a
- disease_b
- directionality
- association_signals
- literature_evidence
- hypotheses
- shared_upstream_hypotheses
- phenotypes
- notes
- curation_status
slot_usage:
  creation_date:
    name: creation_date
    description: Timestamp for initial creation of this comorbidity entry. Keep this
      stable after first set.
  updated_date:
    name: updated_date
    description: Timestamp for the latest substantive update to this comorbidity entry.
      Update this whenever curated content changes.

Induced

name: ComorbidityAssociation
description: An association between two conditions, including directionality, evidence,
  and computational characterizations.
from_schema: https://w3id.org/monarch-initiative/dismech
slot_usage:
  creation_date:
    name: creation_date
    description: Timestamp for initial creation of this comorbidity entry. Keep this
      stable after first set.
  updated_date:
    name: updated_date
    description: Timestamp for the latest substantive update to this comorbidity entry.
      Update this whenever curated content changes.
attributes:
  name:
    name: name
    examples:
    - value: Adolescent Nephronophthisis
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    identifier: true
    alias: name
    owner: ComorbidityAssociation
    domain_of:
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycleStage
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ComorbidityAssociation
    range: string
    required: true
  creation_date:
    name: creation_date
    description: Timestamp for initial creation of this comorbidity entry. Keep this
      stable after first set.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: creation_date
    owner: ComorbidityAssociation
    domain_of:
    - Disease
    - ComorbidityAssociation
    range: string
    recommended: true
    pattern: ^\d{4}-\d{2}-\d{2}T\d{2}:\d{2}:\d{2}(?:\.\d+)?(?:Z|[+\-]\d{2}:\d{2})$
  updated_date:
    name: updated_date
    description: Timestamp for the latest substantive update to this comorbidity entry.
      Update this whenever curated content changes.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: updated_date
    owner: ComorbidityAssociation
    domain_of:
    - Disease
    - ComorbidityAssociation
    range: string
    recommended: true
    pattern: ^\d{4}-\d{2}-\d{2}T\d{2}:\d{2}:\d{2}(?:\.\d+)?(?:Z|[+\-]\d{2}:\d{2})$
  disease_a:
    name: disease_a
    description: First disease in a comorbidity pair
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: disease_a
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    range: ConditionDescriptor
    inlined: true
  disease_b:
    name: disease_b
    description: Second disease in a comorbidity pair
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: disease_b
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    range: ConditionDescriptor
    inlined: true
  directionality:
    name: directionality
    description: Direction of a comorbidity/trajectory association
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: directionality
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    - AssociationSignal
    range: ComorbidityDirectionEnum
  association_signals:
    name: association_signals
    description: Association signals from EHR, registry, or computational sources
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: association_signals
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    range: AssociationSignal
    multivalued: true
    inlined: true
    inlined_as_list: true
  literature_evidence:
    name: literature_evidence
    description: Literature-based evidence items for this association
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: literature_evidence
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    range: EvidenceItem
    multivalued: true
    inlined: true
    inlined_as_list: true
  hypotheses:
    name: hypotheses
    description: Mechanistic or causal hypotheses about the association
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: hypotheses
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    range: ComorbidityHypothesis
    multivalued: true
    inlined: true
    inlined_as_list: true
  shared_upstream_hypotheses:
    name: shared_upstream_hypotheses
    description: Suspected upstream conditions that may explain both A and B
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: shared_upstream_hypotheses
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    range: UpstreamConditionHypothesis
    multivalued: true
    inlined: true
    inlined_as_list: true
  phenotypes:
    name: phenotypes
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: phenotypes
    owner: ComorbidityAssociation
    domain_of:
    - DifferentialDiagnosis
    - Disease
    - ComorbidityAssociation
    range: Phenotype
    multivalued: true
    inlined: true
    inlined_as_list: true
  notes:
    name: notes
    examples:
    - value: Contagious stage where symptoms appear and the bacteria can be spread
        to others.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: notes
    owner: ComorbidityAssociation
    domain_of:
    - GeneticContext
    - OnsetDescriptor
    - PhenotypeContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - Treatment
    - Transmission
    - Diagnosis
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - TermMapping
    - MappingConsistency
    - ComorbidityAssociation
    - AssociationSignal
    - AssociationMetric
    - AssociationStatistics
    - MechanisticHypothesis
    range: string
  curation_status:
    name: curation_status
    description: Curation workflow status
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: curation_status
    owner: ComorbidityAssociation
    domain_of:
    - ComorbidityAssociation
    range: CurationStatusEnum