Class: ClinicalTrial

A clinical trial relevant to treatment or research of a disease

URI: dismech:ClinicalTrial

 classDiagram
    class ClinicalTrial
    click ClinicalTrial href "../ClinicalTrial/"
      ClinicalTrial : description

      ClinicalTrial : evidence





        ClinicalTrial --> "*" EvidenceItem : evidence
        click EvidenceItem href "../EvidenceItem/"



      ClinicalTrial : name

      ClinicalTrial : notes

      ClinicalTrial : phase





        ClinicalTrial --> "0..1" ClinicalTrialPhaseEnum : phase
        click ClinicalTrialPhaseEnum href "../ClinicalTrialPhaseEnum/"



      ClinicalTrial : review_notes

      ClinicalTrial : status





        ClinicalTrial --> "0..1" ClinicalTrialStatusEnum : status
        click ClinicalTrialStatusEnum href "../ClinicalTrialStatusEnum/"



      ClinicalTrial : target_phenotypes





        ClinicalTrial --> "*" PhenotypeDescriptor : target_phenotypes
        click PhenotypeDescriptor href "../PhenotypeDescriptor/"

Slots

Name	Cardinality and Range	Description	Inheritance
name	0..1 String	NCT identifier (e	direct
description	0..1 recommended String	Brief summary or key details of the clinical trial	direct
phase	0..1 recommended ClinicalTrialPhaseEnum	Trial phase (Phase I, Phase II, Phase III, Phase IV, or Not Applicable)	direct
status	0..1 recommended ClinicalTrialStatusEnum	Recruitment or trial status (e	direct
evidence	* EvidenceItem	Supporting evidence with snippets from trial documentation	direct
target_phenotypes	* PhenotypeDescriptor	Phenotypes that this treatment or trial addresses or targets	direct
notes	0..1 String		direct
review_notes	0..1 String		direct

Usages

used by	used in	type	used
Disease	clinical_trials	range	ClinicalTrial

Comments

• Uses NCT identifiers from ClinicalTrials.gov
• Evidence and supporting text can be validated via linkml-reference-validator against ClinicalTrials.gov API

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type	Mapped Value
self	dismech:ClinicalTrial
native	dismech:ClinicalTrial

LinkML Source

Direct

name: ClinicalTrial
description: A clinical trial relevant to treatment or research of a disease
comments:
- Uses NCT identifiers from ClinicalTrials.gov
- Evidence and supporting text can be validated via linkml-reference-validator against
  ClinicalTrials.gov API
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- name
- description
- phase
- status
- evidence
- target_phenotypes
- notes
- review_notes
slot_usage:
  name:
    name: name
    description: NCT identifier (e.g., NCT00000001) or trial name
    identifier: false
  description:
    name: description
    description: Brief summary or key details of the clinical trial
    recommended: true
  phase:
    name: phase
    description: Trial phase (Phase I, Phase II, Phase III, Phase IV, or Not Applicable)
    range: ClinicalTrialPhaseEnum
    recommended: true
  status:
    name: status
    description: Recruitment or trial status (e.g., Recruiting, Completed, Terminated,
      Active not recruiting)
    range: ClinicalTrialStatusEnum
    recommended: true
  evidence:
    name: evidence
    description: Supporting evidence with snippets from trial documentation
    recommended: false

Induced

name: ClinicalTrial
description: A clinical trial relevant to treatment or research of a disease
comments:
- Uses NCT identifiers from ClinicalTrials.gov
- Evidence and supporting text can be validated via linkml-reference-validator against
  ClinicalTrials.gov API
from_schema: https://w3id.org/monarch-initiative/dismech
slot_usage:
  name:
    name: name
    description: NCT identifier (e.g., NCT00000001) or trial name
    identifier: false
  description:
    name: description
    description: Brief summary or key details of the clinical trial
    recommended: true
  phase:
    name: phase
    description: Trial phase (Phase I, Phase II, Phase III, Phase IV, or Not Applicable)
    range: ClinicalTrialPhaseEnum
    recommended: true
  status:
    name: status
    description: Recruitment or trial status (e.g., Recruiting, Completed, Terminated,
      Active not recruiting)
    range: ClinicalTrialStatusEnum
    recommended: true
  evidence:
    name: evidence
    description: Supporting evidence with snippets from trial documentation
    recommended: false
attributes:
  name:
    name: name
    description: NCT identifier (e.g., NCT00000001) or trial name
    examples:
    - value: Adolescent Nephronophthisis
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    identifier: false
    alias: name
    owner: ClinicalTrial
    domain_of:
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycleStage
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ComorbidityAssociation
    range: string
    required: true
  description:
    name: description
    description: Brief summary or key details of the clinical trial
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: description
    owner: ClinicalTrial
    domain_of:
    - Descriptor
    - GeneticContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - HistopathologyFinding
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - FunctionalEffect
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ConditionDescriptor
    - GOEnrichment
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    range: string
    recommended: true
  phase:
    name: phase
    description: Trial phase (Phase I, Phase II, Phase III, Phase IV, or Not Applicable)
    examples:
    - value: Active TB
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: phase
    owner: ClinicalTrial
    domain_of:
    - ClinicalTrial
    - ProgressionInfo
    range: ClinicalTrialPhaseEnum
    recommended: true
  status:
    name: status
    description: Recruitment or trial status (e.g., Recruiting, Completed, Terminated,
      Active not recruiting)
    examples:
    - value: Recruiting
    - value: Completed
    - value: Terminated
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: status
    owner: ClinicalTrial
    domain_of:
    - ClinicalTrial
    - MechanisticHypothesis
    range: ClinicalTrialStatusEnum
    recommended: true
  evidence:
    name: evidence
    description: Supporting evidence with snippets from trial documentation
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: evidence
    owner: ClinicalTrial
    domain_of:
    - PhenotypeContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - Finding
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Diagnosis
    - Inheritance
    - Variant
    - ModelingConsideration
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - AssociationSignal
    - AssociationStatistics
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    range: EvidenceItem
    recommended: false
    multivalued: true
    inlined: true
    inlined_as_list: true
  target_phenotypes:
    name: target_phenotypes
    description: Phenotypes that this treatment or trial addresses or targets
    comments:
    - Should reference phenotype names defined in the same disease's phenotypes list
    - Enables linking treatments/trials to the symptoms/manifestations they aim to
      manage
    - Each phenotype can include ontology term references (HP)
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: target_phenotypes
    owner: ClinicalTrial
    domain_of:
    - ClinicalTrial
    - Treatment
    range: PhenotypeDescriptor
    multivalued: true
    inlined: true
    inlined_as_list: true
  notes:
    name: notes
    examples:
    - value: Contagious stage where symptoms appear and the bacteria can be spread
        to others.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: notes
    owner: ClinicalTrial
    domain_of:
    - GeneticContext
    - OnsetDescriptor
    - PhenotypeContext
    - Dataset
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - Treatment
    - Transmission
    - Diagnosis
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - TermMapping
    - MappingConsistency
    - ComorbidityAssociation
    - AssociationSignal
    - AssociationMetric
    - AssociationStatistics
    - MechanisticHypothesis
    range: string
  review_notes:
    name: review_notes
    examples:
    - value: Added an additional clinically relevant subtype.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: review_notes
    owner: ClinicalTrial
    domain_of:
    - ClinicalTrial
    - Subtype
    - ProgressionInfo
    - Phenotype
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - Treatment
    range: string