> Response constraints
>
> No citable contexts could be retrieved with the available tools in this session, so the response is necessarily a provisional, seed-only synthesis rather than a fully cited literature review.
>
> Manual verification should therefore rely on the seed PubMed records: PMID:25062452 — https://pubmed.ncbi.nlm.nih.gov/25062452/ ; PMID:32402064 — https://pubmed.ncbi.nlm.nih.gov/32402064/ ; PMID:34718620 — https://pubmed.ncbi.nlm.nih.gov/34718620/ ; PMID:35718780 — https://pubmed.ncbi.nlm.nih.gov/35718780/ .


*Blockquote: This blockquote states the session's main limitation: no citable contexts were retrievable with the available tools. It also preserves the seed PubMed URLs for manual verification of the provisional SYCE1 mechanism summary.*