| Field | Value | Notes / Evidence |
|---|---|---|
| Disease name | Postural Orthostatic Tachycardia Syndrome | Dysautonomia characterized by excessive orthostatic tachycardia without orthostatic hypotension (pqac-00000001, pqac-00000003, pqac-00000004) |
| MONDO ID | MONDO:0011479 | Disease-target association retrieved from Open Targets for postural orthostatic tachycardia syndrome (pqac-00000000) |
| OMIM | 604715 | Commonly used disease identifier for POTS in genetic/disease databases |
| ICD-10 | I49.8 | Often mapped clinically under “Other specified cardiac arrhythmias”; coding practice may vary by institution |
| MeSH | Postural Orthostatic Tachycardia Syndrome | Standard biomedical subject heading used in literature indexing |
| Common synonyms | POTS; Postural Tachycardia Syndrome; Orthostatic tachycardia syndrome | Abbreviation and alternate naming used across reviews and clinical literature (pqac-00000003, pqac-00000004) |
| Prevalence | ~0.2% of the general population; up to 1% of the U.S. population; ~1–3 million people in the U.S. | Recent reviews report 0.2% prevalence, while broader U.S. estimates range to 1% and 1–3 million affected individuals (pqac-00000003, pqac-00000001, pqac-00000005) |
| Sex ratio | Predominantly female; ~6:1 female:male; ~70–80% women | Strong female predominance is consistently reported, especially in adolescents and adults of reproductive age (pqac-00000026, pqac-00000005) |
| Typical age of onset | Usually 15–50 years; often adolescents and young adults | Reviews describe onset most commonly in youth to mid-adulthood, often affecting women of reproductive age (pqac-00000029, pqac-00000001, pqac-00000005) |
| Primary subtypes | Neuropathic; Hyperadrenergic; Hypovolemic | These phenotypes are widely described, though overlap between categories is common (pqac-00000058, pqac-00000059) |


*Table: This table summarizes the core disease identifiers and high-yield epidemiologic and clinical characteristics for Postural Orthostatic Tachycardia Syndrome. It is useful as a quick-reference scaffold for a disease knowledge base entry.*