| Entity/scope | Defining biology | Typical age/sites | KB handling |
|---|---|---|---|
| Developmental articular osteochondrosis (latent/manifesta stages) | Focal disturbance/failure of endochondral ossification in growing epiphyseal or articular-epiphyseal cartilage, linked to cartilage-canal vascular failure and localized chondronecrosis; latent/manifesta represent pre-fracture stages before instability or dissection becomes clinically obvious (pqac-00000001, pqac-00000003, pqac-00000005, pqac-00000006, pqac-00000009) | Usually children/adolescents; classic sites include knee, elbow/capitellum, ankle/talus and other developing joints (pqac-00000000, pqac-00000004) | Use as the core disease-family concept for developmental articular lesions; record latent/manifesta as upstream pathobiology or stage terms rather than separate unrelated diseases |
| Osteochondritis dissecans (OCD) | Fissured/unstable or fragmenting stage of articular osteochondrosis in which the osteochondral surface becomes unstable, may cleave/dissect, and causes pain, swelling, catching, or locking; often the stage recognized clinically in humans (pqac-00000000, pqac-00000001, pqac-00000003, pqac-00000007) | Predominantly children/adolescents; most often knee, then elbow and ankle; juvenile form has open physes and better healing potential than adult form (pqac-00000000, pqac-00000004, pqac-00000007) | Represent as a child concept or advanced-stage concept under articular osteochondrosis, with site-specific subrecords (knee OCD, capitellar OCD, talar OCD) when anatomy-specific details differ |
| Named juvenile osteochondroses (e.g., Legg-Calvé-Perthes, Osgood-Schlatter, Sever, Freiberg, Köhler, Scheuermann) | Site-specific pediatric osteochondrosis labels used for distinct anatomic syndromes; they should not be automatically merged with articular osteochondrosis/OCD because biology, anatomy, imaging, natural history, and management differ by entity | Childhood/adolescence; hip/femoral head, tibial tubercle, calcaneal apophysis, metatarsal head, navicular, vertebral endplates depending on syndrome | Curate as separate disease records linked by broader “juvenile osteochondrosis/osteochondrosis” family membership; avoid pooling epidemiology or genetics across these entities without direct evidence |
| Adult spinal “osteochondrosis” terminology | Commonly used degenerative spine terminology rather than the pediatric developmental articular-osteochondrosis process; usage may refer to vertebral endplate/disc degeneration or historical naming conventions rather than OCD biology | Mainly adolescents/adults in the spine, especially thoracic/lumbar vertebral endplates/discs in clinical radiology/orthopedics usage | Keep separate from developmental articular osteochondrosis/OCD in the knowledge base unless a source explicitly addresses Scheuermann-type juvenile vertebral osteochondrosis; do not merge adult degenerative spine usage with pediatric OCD biology |


*Table: This table clarifies how “osteochondrosis” should be scoped in a knowledge base to avoid conflating developmental articular osteochondrosis/OCD with named juvenile osteochondroses or adult degenerative spinal terminology. It is useful for deciding when to create a parent concept versus separate site-specific disease records.*