| Age at onset group | Disease onset provoked by trigger | Exacerbating disease course | Achieved walking without support | Median age of loss of walking without support | Median age of full wheelchair dependency | Median age of death | Median disease duration at death | Citation |
|---|---:|---:|---:|---|---|---|---|---|
| <12 months | 43% | 84% | 0% | n.a. | n.a. | 9 months [6–14] | 7 months [3–10] | (pqac-00000012, pqac-00000010) |
| 1 to <2 years | 66% | 88% | 74% | 2 years | 3 years | 4 years [2–8] | 2 years [1–6] | (pqac-00000012, pqac-00000010) |
| 2 to <4 years | 72% | 93% | 100% | 3 years | 7 years | 9 years [6–15] | 7 years [3–13] | (pqac-00000012, pqac-00000010) |
| 4 to <8 years | 40% | 76% | 100% | 14 years | 18 years | 13 years [9–23] | 6 years [5–17] | (pqac-00000012, pqac-00000010) |
| 8 to <18 years | 54% | 68% | 100% | 25 years | 33 years | 29 years [16–34] | 14 years [4–22] | (pqac-00000012, pqac-00000010) |
| ≥18 years | 21% | 59% | 100% | 44 years | 56 years | 37 years [29–50] | 10 years [4–14] | (pqac-00000012, pqac-00000010) |


*Table: This table summarizes age-at-onset–stratified natural history and prognosis statistics for vanishing white matter disease as reproduced in van der Knaap et al. 2022 from the Hamilton et al. 2018 cohort. It is useful for counseling, prognosis estimation, and trial stratification.*