| Component | Tool(s) attempted | Query examples | Result in this run | Impact on report |
|---|---|---|---|---|
| Papers | `paper_search` | `Waardenburg-Shah`; `EDNRB mutation Hirschsprung`; `Waardenburg syndrome type IV` | No results returned; no citable contexts were returned | Could not support disease claims with tool-retrieved PMID/context evidence |
| Clinical trials | `clinical_trials_search` | `Waardenburg syndrome type IV OR EDNRB OR EDN3`; `Hirschsprung AND (EDNRB OR EDN3 OR Waardenburg)` | 0 trials returned | No trial-based evidence for interventions or pipeline activity |
| Patents | `patent_search` | `EDNRB Hirschsprung Waardenburg`; `Waardenburg-Shah EDNRB EDN3` | No results returned | No patent/translational signals identified in this run |
| OpenTargets | `open_targets_search` | Disease: `Waardenburg syndrome type 4`, `Hirschsprung disease`; Targets: `EDNRB`, `EDN3`, `SOX10` | Tool failed after retries | No disease-target association evidence available from OpenTargets |


*Table: This table summarizes the evidence-retrieval attempts made in the run and the main limitations encountered. It is useful for documenting why the final report could not rely on tool-returned citable contexts or clinical trial/OpenTargets evidence.*