| NCT ID | Title | Phase | Status | Sponsor | Enrollment | Key Design Features |
|---|---|---|---|---|---:|---|
| NCT06268717 | GI Alpha-Gal Study | NA | Completed | University of North Carolina, Chapel Hill | 30 | Double-blind randomized crossover food challenge comparing pork with alpha-gal vs pork without alpha-gal; includes lactulose/C13 mannitol testing, transnasal upper endoscopy with GI biopsies, basophil activation, tryptase, and mRNA/pathology studies (pqac-00000048, pqac-00000049) |
| NCT04828317 | Alpha-gal Pork Challenge | NA | Unknown | University of Virginia | 54 | Pork challenge study in alpha-gal syndrome; interventional design evaluating clinical responses to pork exposure (clinical trial search result in prior tool output) |
| NCT07611435 | Beginning to Assess an Appropriate CONtrol for Oral Food Challenges in Alpha-Gal Syndrome (CoFAR-13) - BeACON4AG | Phase 2 | Not yet recruiting | National Institute of Allergy and Infectious Diseases (NIAID) | 160 | Multisite randomized double-blind crossover diagnostic trial; participants receive alpha-gal knockout pork and wild-type pork on separate visits to compare odds of positive double-blind food challenges and define AGS sub-phenotypes (pqac-00000050, pqac-00000051) |
| NCT07177729 | The α-gal Syndrome - Investigating Immune Reactions to Tick Bites (ImmunoGal) | Observational | Recruiting | Luxembourg Institute of Health | 100 | Prospective cohort enrolling participants within 48 hours of tick removal; longitudinal blood sampling, tick collection/PCR, serology, and multi-omics immune profiling to identify signatures associated with alpha-gal sensitization after tick bites (pqac-00000052) |
| NCT07526558 | Mast Cell Treatment in Post-tick Bite Illness (PTBI) | Phase 2 | Not yet recruiting | University of North Carolina, Chapel Hill | 50 | Randomized double-blind parallel pilot trial testing ketotifen + cromolyn + fexofenadine versus fexofenadine alone for persistent mast cell activation symptoms after post-tick bite illness, including AGS (pqac-00000053) |


*Table: This table summarizes the main clinical trials identified for alpha-gal syndrome and related post-tick bite illness. It is useful for quickly comparing study design, status, enrollment, and the main research focus of each trial.*