| Disease Name | Common Synonyms | ICD-10 | ICD-11 | MeSH ID | MONDO ID | Disease Category | Primary Cause | Key Molecular Target / Mediators | Primary Affected Organ / Cells | Key Epidemiological Data |
|---|---|---|---|---|---|---|---|---|---|---|
| Acetaminophen hepatotoxicity | Paracetamol hepatotoxicity; acetaminophen-induced liver injury; paracetamol-induced liver injury; APAP hepatotoxicity; APAP-induced acute liver injury; acetaminophen overdose liver injury | **T39.1** Poisoning by 4-aminophenol derivatives | **NEEDS CURATION**: ICD-11 poisoning/toxic liver injury terms are applicable, but a single disease-specific ICD-11 identifier for “acetaminophen hepatotoxicity” was not confirmed from retrieved sources | **D056486** | **Not established from retrieved sources** | Complex; drug-induced liver injury; toxic liver disease; acute liver injury / acute liver failure subtype | Acetaminophen/paracetamol overdose, including intentional self-poisoning and unintentional supratherapeutic ingestion | **CYP2E1**-mediated bioactivation to **NAPQI**; glutathione depletion; mitochondrial protein adducts; JNK pathway activation (pqac-00000001, pqac-00000005, pqac-00000008) | Liver, especially **centrilobular/pericentral hepatocytes** with centrilobular necrosis (pqac-00000012, pqac-00000014) | Leading cause of acute liver failure in developed countries; ~**46%** of ALF cases in the US and **60%** in the UK are paracetamol-related; overall ALF incidence in developed countries is **1–6 cases per million/year**; APAP overdose is the leading ALF cause in the US and UK (pqac-00000009, pqac-00000010, pqac-00000011) |


*Table: This table summarizes core identifiers, synonyms, mechanistic hallmarks, affected anatomy, and high-yield epidemiology for acetaminophen hepatotoxicity. It is useful as a compact knowledge-base entry scaffold anchored to retrieved evidence.*