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Dengue

Infectious Disease MONDO:0005502 Arbovirus Infection Neglected tropical disease

Dengue is a mosquito-borne viral disease caused by dengue virus and transmitted by Aedes mosquitoes, with severe cases characterized by plasma leakage and shock.

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Mappings
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Definitions
0
Inheritance
1
Pathophysiology
0
Histopathology
2
Phenotypes
0
Genes
0
Treatments
0
Subtypes
0
Differentials
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Datasets
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Trials
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Pathophysiology

1
Plasma leakage leading to shock in severe dengue
Severe dengue involves plasma leakage that can progress to hypovolemic shock.
Show evidence (1 reference)
PMID:32265181 SUPPORT
"Plasma leakages is the main pathophysiological hallmark that distinguishes DHF from DF. Severe plasma leakage can result in hypovolemic shock."
The review highlights plasma leakage and shock in severe dengue.
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Phenotypes

2
Immune(1) Metabolism(1)
Immune 1
Skin rash FREQUENT Skin rash (HP:0000988)
Show evidence (1 reference)
PMID:17448935 NO_EVIDENCE
"The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
Rash is a typical clinical feature of dengue.
Metabolism 1
Fever VERY_FREQUENT Fever (HP:0001945)
Show evidence (1 reference)
PMID:17448935 NO_EVIDENCE
"The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
Fever is a typical clinical feature of dengue.
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Source YAML

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name: Dengue
creation_date: '2025-12-04T16:57:31Z'
updated_date: '2026-02-16T20:19:38Z'
category: Infectious Disease
description: Dengue is a mosquito-borne viral disease caused by dengue virus and transmitted by Aedes mosquitoes, with severe cases characterized by plasma leakage and shock.
disease_term:
  term:
    id: MONDO:0005502
    label: dengue disease
  preferred_term: dengue disease
parents:
- Arbovirus Infection
- Neglected tropical disease
infectious_agent:
- name: Dengue virus
  infectious_agent_term:
    preferred_term: Dengue virus
    term:
      id: NCBITaxon:12637
      label: Dengue virus
  evidence:
  - reference: PMID:34171205
    supports: SUPPORT
    snippet: Dengue is a vector-borne viral disease caused by the flavivirus dengue virus (DENV).
    explanation: The review identifies dengue virus as the causative flavivirus.
agent_life_cycle:
  description: Dengue virus cycles between humans and Aedes mosquito vectors.
  hosts:
  - preferred_term: human
    term:
      id: NCBITaxon:9606
      label: Homo sapiens
    role: definitive host
  - preferred_term: Aedes aegypti
    term:
      id: NCBITaxon:7159
      label: Aedes aegypti
    role: vector
  - preferred_term: Aedes albopictus
    term:
      id: NCBITaxon:7160
      label: Aedes albopictus
    role: vector
transmission:
- name: Aedes mosquito transmission
  description: Aedes aegypti and Aedes albopictus transmit dengue virus to humans.
  evidence:
  - reference: PMID:23817881
    supports: SUPPORT
    snippet: It is usually transmitted to humans through the bite of an infected Aedes aegypti or Aedes albopictus mosquito.
    explanation: The abstract specifies Aedes aegypti and Aedes albopictus as vectors.
pathophysiology:
- name: Plasma leakage leading to shock in severe dengue
  description: Severe dengue involves plasma leakage that can progress to hypovolemic shock.
  evidence:
  - reference: PMID:32265181
    supports: SUPPORT
    snippet: Plasma leakages is the main pathophysiological hallmark that distinguishes DHF from DF. Severe plasma leakage can result in hypovolemic shock.
    explanation: The review highlights plasma leakage and shock in severe dengue.
phenotypes:
- name: Fever
  category: Systemic
  frequency: VERY_FREQUENT
  phenotype_term:
    preferred_term: Fever
    term:
      id: HP:0001945
      label: Fever
  evidence:
  - reference: PMID:17448935
    supports: NO_EVIDENCE
    snippet: The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia.
    explanation: Fever is a typical clinical feature of dengue.
- name: Skin rash
  category: Dermatologic
  frequency: FREQUENT
  phenotype_term:
    preferred_term: Skin rash
    term:
      id: HP:0000988
      label: Skin rash
  evidence:
  - reference: PMID:17448935
    supports: NO_EVIDENCE
    snippet: The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia.
    explanation: Rash is a typical clinical feature of dengue.