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Chikungunya

Infectious Disease MONDO:0017941 Arbovirus Infection Neglected tropical disease

Chikungunya is an arboviral disease caused by chikungunya virus and transmitted by Aedes mosquitoes, presenting with acute fever, rash, and incapacitating arthralgia.

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Mappings
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Definitions
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Inheritance
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Pathophysiology
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Histopathology
3
Phenotypes
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Genes
1
Treatments
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Subtypes
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Differentials
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Datasets
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Trials
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Phenotypes

3
Immune(1) Metabolism(1) Constitutional(1)
Immune 1
Skin rash FREQUENT Skin rash (HP:0000988)
Show evidence (1 reference)
PMID:17448935 SUPPORT
"The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
Rash is a typical feature of acute chikungunya.
Metabolism 1
Fever VERY_FREQUENT Fever (HP:0001945)
Show evidence (1 reference)
PMID:17448935 SUPPORT
"The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
Fever is a typical feature of acute chikungunya.
Constitutional 1
Arthralgia VERY_FREQUENT Arthralgia (HP:0002829)
Show evidence (1 reference)
PMID:17448935 SUPPORT
"The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
Arthralgia is a hallmark of acute chikungunya.
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Treatments

1
Symptomatic management MAXO:0000950
Supportive care for acute chikungunya.
Show evidence (1 reference)
PMID:29533749 SUPPORT
"Treatment of acute CHIK is symptomatic"
The abstract notes that acute chikungunya treatment is symptomatic.
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Source YAML

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name: Chikungunya
creation_date: '2026-01-26T15:56:41Z'
updated_date: '2026-01-26T15:56:41Z'
category: Infectious Disease
description: >-
  Chikungunya is an arboviral disease caused by chikungunya virus and
  transmitted by Aedes mosquitoes, presenting with acute fever, rash,
  and incapacitating arthralgia.
disease_term:
  term:
    id: MONDO:0017941
    label: chikungunya
  preferred_term: Chikungunya
parents:
- Arbovirus Infection
- Neglected tropical disease
infectious_agent:
- name: Chikungunya virus
  infectious_agent_term:
    preferred_term: Chikungunya virus
    term:
      id: NCBITaxon:37124
      label: Chikungunya virus
  description: Alphavirus responsible for chikungunya disease.
  evidence:
  - reference: PMID:29533749
    supports: SUPPORT
    snippet: "Chikungunya virus (CHIKV) is an arthropod-borne alphavirus"
    explanation: The abstract identifies CHIKV as an alphavirus.
agent_life_cycle:
  description: Chikungunya virus cycles between human hosts and Aedes mosquito vectors.
  hosts:
  - preferred_term: human
    term:
      id: NCBITaxon:9606
      label: Homo sapiens
    role: definitive host
  vectors:
  - Aedes aegypti (NCBITaxon:7159)
  - Aedes albopictus (NCBITaxon:7160)
transmission:
- name: Aedes mosquito transmission
  description: Aedes aegypti and Aedes albopictus transmit chikungunya virus.
  evidence:
  - reference: PMID:29533749
    supports: SUPPORT
    snippet: "Chikungunya virus (CHIKV) is an arthropod-borne alphavirus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes."
    explanation: The abstract specifies Aedes aegypti and Aedes albopictus as vectors.
phenotypes:
- name: Fever
  category: Systemic
  frequency: VERY_FREQUENT
  phenotype_term:
    preferred_term: Fever
    term:
      id: HP:0001945
      label: Fever
  evidence:
  - reference: PMID:17448935
    supports: SUPPORT
    snippet: "The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
    explanation: Fever is a typical feature of acute chikungunya.
- name: Skin rash
  category: Dermatologic
  frequency: FREQUENT
  phenotype_term:
    preferred_term: Skin rash
    term:
      id: HP:0000988
      label: Skin rash
  evidence:
  - reference: PMID:17448935
    supports: SUPPORT
    snippet: "The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
    explanation: Rash is a typical feature of acute chikungunya.
- name: Arthralgia
  category: Musculoskeletal
  frequency: VERY_FREQUENT
  phenotype_term:
    preferred_term: Arthralgia
    term:
      id: HP:0002829
      label: Arthralgia
  evidence:
  - reference: PMID:17448935
    supports: SUPPORT
    snippet: "The disease typically consists of an acute illness characterised by fever, rash, and incapacitating arthralgia."
    explanation: Arthralgia is a hallmark of acute chikungunya.
treatments:
- name: Symptomatic management
  description: Supportive care for acute chikungunya.
  treatment_term:
    preferred_term: supportive care
    term:
      id: MAXO:0000950
      label: supportive care
  evidence:
  - reference: PMID:29533749
    supports: SUPPORT
    snippet: "Treatment of acute CHIK is symptomatic"
    explanation: The abstract notes that acute chikungunya treatment is symptomatic.