{
  "reviewed_commit": "ff2061ac274cdb1a91f563647767a1f4761ca6f0",
  "module_sha256": "017a2e0e087b9071c8d496bb9cda9012d76c140f6a905c9577a2bd9437da114f",
  "node_names": [
    "Senescence-Inducing Stress",
    "Senescence-Associated Cell Cycle Arrest",
    "Senescence-Associated Secretory Phenotype",
    "HLA-E Display by Senescent Cells",
    "Reduced NK-Cell Cytotoxicity toward Senescent Cells",
    "Impaired Immune Clearance of Senescent Cells",
    "Senescent Cell Accumulation",
    "Tissue Dysfunction and Age-Related Pathology"
  ],
  "graph_edges": 28,
  "orphan_targets": [],
  "checks": {
    "folded_hyphens": [],
    "short_snippets": [],
    "snippet_grading": [],
    "title_only_snippets": [],
    "reference_title_mismatches": []
  },
  "validation_outputs": {
    "schema": "No issues found",
    "terms": "scripts/run_term_validator.sh validate-data kb/modules/cellular_senescence.yaml -s src/dismech/schema/dismech.yaml -t Disease --labels -c conf/oak_config.yaml\n\u2705 Validation passed",
    "references": "Cache directory: references_cache\n\nValidating kb/modules/cellular_senescence.yaml against schema src/dismech/schema/dismech.yaml\n\nValidating docs/reports/senescent-cell-representation/existing-schema.yaml against schema src/dismech/schema/dismech.yaml\n\nValidating docs/reports/senescent-cell-representation/wound-context.yaml against schema src/dismech/schema/dismech.yaml\n\nValidation Summary:\n  Files validated: 3\n  Total checks: 0\n  All validations passed!\n  Snippets checked: 50/50 verified against cached references"
  },
  "ontology_lookups": "review-term-lookups.json",
  "review_dispositions": {
    "1": "Included all four generated reference caches after explicit user authorization.",
    "2": "Moved HLA-E induction to the SASP parent with the primary cytokine/p38 result; did not infer that ATM inhibition excludes all DNA-damage contributions.",
    "3": "Renamed the reusable target HLA-E Display by Senescent Cells; retained fibroblast/skin scope in descriptors and evidence.",
    "4": "Added HGNC bindings for HLA-E (hgnc:4962) and KLRC1/NKG2A (hgnc:6374), verified by the configured OAK adapter and official HGNC REST service.",
    "5": "Looked up GO:0002428 but did not assert a peptide-processing/presentation pathway from the inhibitory-display experiments; senescence-specific antigen identity remains unresolved in the source.",
    "6": "Retained broad immune effector process because the clearance claim spans effector arms.",
    "7": "Retained the distinction between a process qualifier and population burden.",
    "8": "Transcript-versus-protein rationale remains explicit in the biochemical notes.",
    "9": "Kept report-specific scripts and machine-readable records beside their fixtures for reproducibility.",
    "10": "Refined the existing skin-explant model fibroblast binding to CL:0002620 without changing its experimental claims."
  }
}