{
  "base_commit": "1cc412fddde5aacb0cc66311a96e25d67465fdb9",
  "criterion": "Pathophysiology name contains senesc (case-insensitive) OR biological_processes directly uses one of GO:0090398, GO:0090399, GO:0090400, GO:0090402, GO:0090403. Text mentions elsewhere and inferred ancestor closure excluded.",
  "summary": {
    "disorders": {
      "files": 3044,
      "matching_files": 39,
      "senescence_name_or_GO_nodes": 44,
      "with_cell_types": 30,
      "with_multiple_cell_types": 8,
      "with_senescent_display_label": 0,
      "with_locations": 12,
      "with_conforms_to": 15
    },
    "modules": {
      "files": 177,
      "matching_files": 7,
      "senescence_name_or_GO_nodes": 10,
      "with_cell_types": 2,
      "with_multiple_cell_types": 1,
      "with_senescent_display_label": 1,
      "with_locations": 0,
      "with_conforms_to": 0
    }
  },
  "rows": [
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    {"file": "kb/disorders/Activated_PI3K-delta_Syndrome.yaml", "node": "Senescent T-cell skewing", "cell_terms": ["CL:0000624", "CL:0000625"], "cell_labels": ["CD4-positive alpha-beta T cell", "CD8-positive alpha-beta T cell"], "process_terms": ["GO:0090398", "GO:0006924"], "conforms_to": null},
    {"file": "kb/disorders/Adult_T_Cell_Leukemia_Lymphoma.yaml", "node": "TP53-Mutant Senescence Escape", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398"], "conforms_to": "viral_oncogenesis#Host Tumor Suppressor Inactivation and Signaling Hijack"},
    {"file": "kb/disorders/Ageing_Associated_Decline_in_Intrinsic_Capacity.yaml", "node": "Senescent Cell Accumulation in Ageing Tissue", "cell_terms": ["CL:0000057"], "cell_labels": ["fibroblast"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/Alzheimer_Disease.yaml", "node": "Senescent Cell Accumulation", "cell_terms": ["CL:0000127", "CL:0000129", "CL:0002453", "CL:0000679"], "cell_labels": ["Astrocyte", "Microglia", "Oligodendrocyte precursor cell", "Excitatory neuron"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/Androgenetic_Alopecia.yaml", "node": "Premature Senescence of Balding Dermal Papilla Cells", "cell_terms": ["CL:2000083"], "cell_labels": ["scalp hair follicle dermal papilla cell"], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Arts_syndrome.yaml", "node": "Neural Stem Cell Senescence-Like State", "cell_terms": ["CL:0000047"], "cell_labels": ["neural stem cell"], "process_terms": [], "conforms_to": null},
    {"file": "kb/disorders/BRAF_V600_Mutant_Melanoma.yaml", "node": "Oncogene-Induced Melanocytic Growth-Arrest Barrier", "cell_terms": ["CL:0000148"], "cell_labels": ["melanocyte"], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Cervical_Artery_Dissection.yaml", "node": "Molecular Stress and Vascular Remodeling Signatures", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398", "GO:0007005"], "conforms_to": null},
    {"file": "kb/disorders/Chronic_Obstructive_Pulmonary_Disease.yaml", "node": "Cellular Senescence", "cell_terms": ["CL:0002368", "CL:0000057"], "cell_labels": ["airway epithelial cell", "fibroblast"], "process_terms": ["GO:0090398", "GO:0006954"], "conforms_to": null},
    {"file": "kb/disorders/Cockayne_Syndrome.yaml", "node": "Accelerated Cellular Senescence", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Dyskeratosis_Congenita.yaml", "node": "Critically Short Telomeres and Replicative Senescence", "cell_terms": ["CL:0000037"], "cell_labels": ["Hematopoietic stem cell"], "process_terms": ["GO:0090399", "GO:0006915", "GO:0030330"], "conforms_to": null},
    {"file": "kb/disorders/Dyskeratosis_Congenita_Autosomal_Recessive_6.yaml", "node": "Hematopoietic Stem Cell Exhaustion", "cell_terms": ["CL:0000037"], "cell_labels": ["hematopoietic stem cell"], "process_terms": ["GO:0090399"], "conforms_to": null},
    {"file": "kb/disorders/Hutchinson-Gilford_Progeria_Syndrome.yaml", "node": "Cellular senescence", "cell_terms": ["CL:0000057"], "cell_labels": ["Fibroblast"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescence-Associated Cell Cycle Arrest"},
    {"file": "kb/disorders/Idiopathic_Pulmonary_Fibrosis.yaml", "node": "AT2 cell senescence and SASP", "cell_terms": ["CL:0002063"], "cell_labels": ["type II pneumocyte"], "process_terms": ["GO:0090398", "GO:0007179"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/Idiopathic_Pulmonary_Fibrosis.yaml", "node": "Aberrant basaloid cell emergence", "cell_terms": ["CL:0000646"], "cell_labels": ["aberrant basaloid epithelial cell"], "process_terms": ["GO:0001837", "GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Idiopathic_Pulmonary_Fibrosis.yaml", "node": "Senescent myofibroblast persistence and apoptosis resistance", "cell_terms": [], "cell_labels": [], "process_terms": [], "conforms_to": null},
    {"file": "kb/disorders/Inclusion_Body_Myositis.yaml", "node": "Fibro-Adipogenic Progenitor Senescence", "cell_terms": ["CL:0000057"], "cell_labels": ["Fibro-adipogenic progenitor"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/Inherited_Aplastic_Anemia.yaml", "node": "Telomere Attrition", "cell_terms": ["CL:0000037"], "cell_labels": ["Hematopoietic stem cell"], "process_terms": ["GO:0000723", "GO:0090399"], "conforms_to": null},
    {"file": "kb/disorders/Ischemic_Stroke.yaml", "node": "Astrocyte and Cerebral Endothelial Cell Senescence", "cell_terms": ["CL:0000127", "CL:0000115"], "cell_labels": ["astrocyte", "endothelial cell"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/Lethal_Polymalformative_Syndrome_Boissel_Type.yaml", "node": "Impaired fibroblast proliferation and premature senescence", "cell_terms": ["CL:0000057"], "cell_labels": ["fibroblast"], "process_terms": ["GO:0090398", "GO:0008283"], "conforms_to": null},
    {"file": "kb/disorders/Li-Fraumeni_Syndrome.yaml", "node": "Senescence Escape", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Long_COVID.yaml", "node": "Striatal Dopaminergic Dysfunction", "cell_terms": ["CL:0000700"], "cell_labels": ["Midbrain dopaminergic neuron"], "process_terms": ["GO:0001963", "GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Melanoma_in_Congenital_Melanocytic_Nevus.yaml", "node": "Genetic Mutations", "cell_terms": ["CL:0000148", "CL:0011012"], "cell_labels": ["melanocyte", "neural crest cell"], "process_terms": ["GO:0000165", "GO:0090398", "GO:0000723"], "conforms_to": null},
    {"file": "kb/disorders/Multiple_Sclerosis.yaml", "node": "Chronic Inflammation-Induced Oligodendroglial and Glial Senescence", "cell_terms": ["CL:0000128", "CL:0000127", "CL:0000129"], "cell_labels": ["Oligodendrocyte", "Astrocyte", "Microglial cell"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/Myotonic_Dystrophy_Type_1.yaml", "node": "Satellite Cell Premature Senescence", "cell_terms": ["CL:0000594"], "cell_labels": ["skeletal muscle satellite cell"], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Nephronophthisis.yaml", "node": "DNA Damage and Senescence", "cell_terms": [], "cell_labels": [], "process_terms": [], "conforms_to": null},
    {"file": "kb/disorders/Nonimmune_Chronic_Idiopathic_Neutropenia_of_Adults.yaml", "node": "Granulocyte Replicative Senescence", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090399"], "conforms_to": null},
    {"file": "kb/disorders/Osteoarthritis.yaml", "node": "Chondrocyte Senescence", "cell_terms": ["CL:0000138"], "cell_labels": ["Chondrocyte"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/Osteoporosis.yaml", "node": "Senescent Cell Accumulation in the Bone Microenvironment", "cell_terms": ["CL:0000137"], "cell_labels": ["Osteocyte"], "process_terms": ["GO:0090398"], "conforms_to": "cellular_senescence#Senescent Cell Accumulation"},
    {"file": "kb/disorders/POT1_Tumor_Predisposition_Syndrome.yaml", "node": "Extended Replicative Capacity of Incipient Cancer Cells", "cell_terms": ["CL:0000148", "CL:0000115", "CL:0000236", "CL:0000125"], "cell_labels": ["melanocyte", "endothelial cell", "B cell", "glial cell"], "process_terms": ["GO:0090399"], "conforms_to": null},
    {"file": "kb/disorders/Pancreatic_Ductal_Adenocarcinoma.yaml", "node": "Senescent Myofibroblast Immunosuppression", "cell_terms": [], "cell_labels": [], "process_terms": [], "conforms_to": null},
    {"file": "kb/disorders/Pilocytic_Astrocytoma.yaml", "node": "Oncogene-Induced Senescence", "cell_terms": ["CL:0000047"], "cell_labels": ["neural stem cell"], "process_terms": ["GO:0090398", "GO:0008285"], "conforms_to": "senescence_tumor_suppression#Senescence-Associated Tumor-Suppressive Arrest"},
    {"file": "kb/disorders/Pilocytic_Astrocytoma.yaml", "node": "Senescence-Constrained Low-Grade Progression Barrier", "cell_terms": [], "cell_labels": [], "process_terms": [], "conforms_to": "senescence_tumor_suppression#Barrier to Malignant Transformation"},
    {"file": "kb/disorders/Portal_Hypertension_Noncirrhotic_2.yaml", "node": "Cellular Senescence in Endothelium and Lymphocytes", "cell_terms": ["CL:0000115"], "cell_labels": ["endothelial cell"], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Primary_Sclerosing_Cholangitis.yaml", "node": "Cholangiocyte Senescence", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398"], "conforms_to": "cholestatic_liver_injury#Bile Acid-Mediated Hepatocyte and Cholangiocyte Injury"},
    {"file": "kb/disorders/Revesz_Syndrome.yaml", "node": "Extreme Telomere Shortening", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090399", "GO:0007004"], "conforms_to": null},
    {"file": "kb/disorders/Revesz_Syndrome.yaml", "node": "Pulmonary Involvement and Respiratory Failure", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090399"], "conforms_to": null},
    {"file": "kb/disorders/SARS1-Related_Neurodevelopmental_Disorder.yaml", "node": "Cellular Senescence with a Senescence-Associated Secretory Phenotype", "cell_terms": ["CL:0000057"], "cell_labels": ["patient-derived dermal fibroblast"], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/disorders/Sclerosing_Cholangitis.yaml", "node": "Cholangiocyte Senescence-Associated Fibrogenesis", "cell_terms": ["CL:1000488", "CL:0000632"], "cell_labels": ["Cholangiocyte", "Hepatic stellate cell"], "process_terms": ["GO:0090398", "GO:0030198"], "conforms_to": "cholestatic_liver_injury#Ductular Reaction and Cholangiocyte-Driven Fibrogenesis"},
    {"file": "kb/disorders/Werner_Syndrome.yaml", "node": "Accelerated Replicative Senescence", "cell_terms": ["CL:0002620"], "cell_labels": ["skin fibroblast"], "process_terms": ["GO:0090399"], "conforms_to": "cellular_senescence#Senescence-Associated Cell Cycle Arrest"},
    {"file": "kb/disorders/Werner_Syndrome.yaml", "node": "Senescence-Associated Adipogenic Failure", "cell_terms": [], "cell_labels": [], "process_terms": [], "conforms_to": null},
    {"file": "kb/disorders/Wiedemann-Rautenstrauch_Syndrome.yaml", "node": "Nucleolar Disruption, p53 Activation and Premature Senescence", "cell_terms": ["CL:0002620"], "cell_labels": ["skin fibroblast"], "process_terms": ["GO:0090398", "GO:0007000", "GO:0008283"], "conforms_to": null},
    {"file": "kb/disorders/XFE_Progeroid_Syndrome.yaml", "node": "Premature Cellular Senescence", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/modules/cellular_senescence.yaml", "node": "Senescence-Inducing Stress", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0006974"], "conforms_to": null},
    {"file": "kb/modules/cellular_senescence.yaml", "node": "Senescence-Associated Cell Cycle Arrest", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398", "GO:0090399"], "conforms_to": null},
    {"file": "kb/modules/cellular_senescence.yaml", "node": "Senescence-Associated Secretory Phenotype", "cell_terms": ["CL:0000057"], "cell_labels": ["Senescent Fibroblast"], "process_terms": ["GO:0006954", "GO:0001816", "GO:0019221"], "conforms_to": null},
    {"file": "kb/modules/cellular_senescence.yaml", "node": "Senescent Cell Accumulation", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398"], "conforms_to": null},
    {"file": "kb/modules/cholestatic_liver_injury.yaml", "node": "Bile Acid-Mediated Hepatocyte and Cholangiocyte Injury", "cell_terms": ["CL:0000182", "CL:1000488"], "cell_labels": ["hepatocyte", "cholangiocyte"], "process_terms": ["GO:0006915", "GO:0090398", "GO:0006954"], "conforms_to": null},
    {"file": "kb/modules/enabling_replicative_immortality.yaml", "node": "Replicative Senescence and Crisis Barrier", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090399"], "conforms_to": null},
    {"file": "kb/modules/il11_erk_ampk_mtor_aging.yaml", "node": "Cellular Senescence and Metabolic Decline", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398", "GO:0006954"], "conforms_to": null},
    {"file": "kb/modules/mitochondrial_dysfunction.yaml", "node": "Mitochondrial Contribution to Senescence and Inflammation", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0006954"], "conforms_to": null},
    {"file": "kb/modules/senescence_tumor_suppression.yaml", "node": "Senescence-Associated Tumor-Suppressive Arrest", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0090398", "GO:0008285"], "conforms_to": null},
    {"file": "kb/modules/telomere_attrition.yaml", "node": "Telomere-Initiated DNA Damage and Replicative Senescence", "cell_terms": [], "cell_labels": [], "process_terms": ["GO:0006974", "GO:0090399"], "conforms_to": null}
  ]
}